Protein detail

T4S18

Transmembrane 4 L6 family member 18

Entry name T4S18	UniProt ID Q96CE8	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 4	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Transmembrane 4 L6 family member 18

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Accessory Factors Involved in Transport

Transmembrane

10..30; Helical; 50..70; Helical; 94..114; Helical; 158..178; Helical

Transmembrane Count

Ensembl

ENSG00000163762

Entrez Gene Symbol

TM4SF18

Gene Synonym

L6D

Gene Description

Transmembrane 4 L six family member 18

Chromosome

Position

149318498-149334414

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway5

Protein Function

Transporters:Accessory Factors Involved in Transport

Cellular Component

GO:0016020 membrane

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence9

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	37016580 37767799

Sequence, Structure & Domains5

Sequences

Length

201

Mass

22,277

Sequence

MGSRKCGGCLSCLLIPLALWSIIVNILLYFPNGQTSYASSNKLTNYVWYFEGICFSGIMMLIVTTVLLVLENNNNYKCCQSENCSKKYVTLLSIIFSSLGIAFSGYCLVISALGLVQGPYCRTLDGWEYAFEGTAGRFLTDSSIWIQCLEPAHVVEWNIILFSILITLSGLQVIICLIRVVMQLSKILCGSYSVIFQPGII

Domain & Motif Annotations

Protein Families

L6 tetraspanin family

Sequence Similarities

Belongs to the L6 tetraspanin family.

Clinical Relevance1

Antibody (2)

HPA058640 HPA069378

Supporting Publications1

PMID	Title	Abstract
27605433	Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo.	No abstract available