Protein detail
ASTRA
Protein Aster-A (GRAM domain-containing protein 1A)
Protein symbol ASTRA | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protein Aster-A (GRAM domain-containing protein 1A)
Protein Class
Plasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- Predicted intracellular proteins
Transmembrane
610..630; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ90346KIAA1533
Gene Description
GRAM domain containing 1A
Chromosome
19
Position
34994784-35026471
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEarly spermatids
Function & Pathway
Protein Function
- Transporters
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
724
Mass
80,680
Sequence
MFDTTPHSGRSTPSSSPSLRKRLQLLPPSRPPPEPEPGTMVEKGSDSSSEKGGVPGTPSTQSLGSRNFIRNSKKMQSWYSMLSPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVSPLQLNGLGTPKEVGDVIALSDITSSGAADRSQEPSPVGSRRGHVTPNLSRASSDADHGAEEDKEEQVDSQPDASSSQTVTPVAEPPSTEPTQPDGPTTLGPLDLLPSEELLTDTSNSSSSTGEEADLAALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQCKFTDVTLSPWSGDSKCHQRRVLTYTIPISNPLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKNSWSGIEDYFHHLERELAKAEKLSLEEGGKDARGLLSGLRRRKRPLSWRAHGDGPQHPDPDPCARAGIHTSGSLSSRFSEPSVDQGPGAGIPSALVLISIVICVSLIILIALNVLLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQKQFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVSDPPFDTQPRPDDSFS
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96CP6-1; Sequence=Displayed; Name=2; IsoId=Q96CP6-2; Sequence=VSP_025465, VSP_025466; Name=3; IsoId=Q96CP6-3; Sequence=VSP_025466
Alternative Sequence
74..80; Missing (in isoform 2); 615..618; Missing (in isoform 2 and isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1..18; Low complexity; 57..66; Polar residues; 300..312; Polar residues; 326..336; Low complexity; 563..575; Basic and acidic residues
Domain (CC)
GRAM domain binds phosphatidylserine in the PM and mediates protein recruitment to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM.; DOMAIN: VASt (VAD1 Analog of StAR-related lipid transfer) domain, also known as ASTER (Greek for star) domain is a sterol-binding domain.
Domain (FT)
91..158; GRAM; 367..538; VASt
Region
1..66; Disordered; 256..336; Disordered; 560..579; Disordered