Protein detail
CC124
Coiled-coil domain-containing protein 124
Entry name CC124 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Coiled-coil domain-containing protein 124
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
Lso2oxs1
Gene Description
Coiled-coil domain containing 124
Chromosome
19
Position
17933015-17943991
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization2
Tissue SpecificbrainCell SpecificAdrenal medulla cells
Function & Pathway5
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function (3)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence8
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CCDC124EIF1BEIF2D | O60739P41214Q96CT7 | 0:0:0 | hu.MAP | |||
| CCDC124CHMP6EIF3JELLSNF8VPS25VPS36 | O75822P55199Q86VN1Q96CT7Q96FZ7Q96H20Q9BRG1 | 1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4056 | ||
| CCDC124FERMT1HMGB2 | P26583Q96CT7Q9BQL6 | 0:0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer Precipitation | Mass spectrometryR Sequencing | 24 | 341862433040859127863537311969683228482532341357330358143561146232944193397661583639856437786918381689063940901534817906289865852789410428590090309501853832153534445582291482393040859132089743 |
Sequence, Structure & Domains9
Sequences
Length
223
Mass
25,835
Sequence
MPKKFQGENTKSAAARARRAEAKAAADAKKQKELEDAYWKDDDKHVMRKEQRKEEKEKRRLDQLERKKETQRLLEEEDSKLKGGKAPRVATSSKVTRAQIEDTLRRDHQLREAPDTAEKAKSHLEVPLEENVNRRVLEEGSVEARTIEDAIAVLSVAEEAADRHPERRMRAAFTAFEEAQLPRLKQENPNMRLSQLKQLLKKEWLRSPDNPMNQRAVPFNAPK
3D Structural Models
3D Structure
Electron microscopy (6)
Domain & Motif Annotations
Compositional Bias
18..74; Basic and acidic residues; 99..126; Basic and acidic residues
Coiled Coil
15..82
Region
1..126; Disordered; 204..223; Disordered
Protein Families
CCDC124 family
Sequence Similarities
Belongs to the CCDC124 family.
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No abstract available |