Protein detail
AP2M1
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Protein symbol AP2M1 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count | Protein classification Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsTransporters |
Basic Information
Protein Names
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Protein Class
Disease related genesEssential proteinsHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsTransporters
Protein Function
- Transporters
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Potential drug targets
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
AP50CLAPM1mu2
Gene Description
Adaptor related protein complex 2 subunit mu 1
Chromosome
3
Position
184174689-184184214
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificcDCBlood Cell Specificmyeloid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Transporters
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Potential drug targets
- Disease related genes
Cellular Component
- GO:0005765 lysosomal membrane
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005905 clathrin-coated pit
- GO:0008021 synaptic vesicle
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0030122 AP-2 adaptor complex
- GO:0030666 endocytic vesicle membrane
- GO:0030669 clathrin-coated endocytic vesicle membrane
- GO:0031410 cytoplasmic vesicle
- GO:0036020 endolysosome membrane
- GO:0045334 clathrin-coated endocytic vesicle
- GO:0070062 extracellular exosome
- GO:0098794 postsynapse
- GO:0098894 extrinsic component of presynaptic endocytic zone membrane
- GO:0098978 glutamatergic synapse
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-8856825 cargo recognition for clathrin mediated endocytosis
- R-hsa-8856828 clathrin mediated endocytosis
- R-hsa-9918485 dengue virus attachment and entry
- R-hsa-9839923 dengue virus infection
- R-hsa-3928665 eph ephrin mediated repulsion of cells
- R-hsa-2682334 eph ephrin signaling
- R-hsa-190873 gap junction degradation
- R-hsa-157858 gap junction trafficking and regulation
- R-hsa-162906 hiv infection
- R-hsa-162909 host interactions of hiv factors
- R-hsa-5663205 infectious disease
- R-hsa-373760 l1cam interactions
- R-hsa-8964038 ldl clearance
- R-hsa-199991 membrane trafficking
- R-hsa-2132295 mhc class ii antigen presentation
- R-hsa-167590 nef mediated cd4 down regulation
- R-hsa-182218 nef mediated cd8 down regulation
- R-hsa-164938 nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
- R-hsa-9675108 nervous system development
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-4086400 pcp ce pathway
- R-hsa-174824 plasma lipoprotein assembly remodeling and clearance
- R-hsa-8964043 plasma lipoprotein clearance
- R-hsa-9679191 potential therapeutics for sars
- R-hsa-437239 recycling pathway of l1
- R-hsa-177504 retrograde neurotrophin signalling
- R-hsa-9679506 sars cov infections
- R-hsa-166520 signaling by ntrks
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-195721 signaling by wnt
- R-hsa-164952 the role of nef in hiv 1 replication and disease pathogenesis
- R-hsa-399719 trafficking of ampa receptors
- R-hsa-416993 trafficking of glur2 containing ampa receptors
- R-hsa-112315 transmission across chemical synapses
- R-hsa-382551 transport of small molecules
- R-hsa-5653656 vesicle mediated transport
- R-hsa-9824446 viral infection pathways
- R-hsa-8866427 vldlr internalisation and degradation
- R-hsa-5140745 wnt5a dependent internalization of fzd2 fzd5 and ror2
- R-hsa-5099900 wnt5a dependent internalization of fzd4
Canonical Pathways
- M165 Pid syndecan 4 pathway
- M232 Pid ecadherin stabilization pathway
- M71 Pid ilk pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| AP2M1 | AAK1 | Q2M2I8 | T | 156 | phosphorylation | SIGNORProtMapperphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:11877461SIGNOR:11877461phosphoELM:11877457phosphoELM:11877461 |
| AP2M1 | AAK1 | Q2M2I8 | T | 154 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| AP2M1 | BMP2K | Q9NSY1 | T | 156 | phosphorylation | PhosphoSite | |
| AP2M1 | LRRK2 | Q5S007 | T | 156 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
6 records.
Protein Complex Composition
10 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | ELISA | 1 | 26775013 |
Sequence, Structure & Domains
Sequences
Length
435
Mass
49,655
Sequence
MIGGLFIYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYETRC
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96CW1-1; Sequence=Displayed; Name=2; IsoId=Q96CW1-2; Sequence=VSP_034599
Alternative Sequence
141..142; Missing (in isoform 2)
3D Structural Models
Turn
297..299; 346..349
Helix
28..35; 75..93; 98..103; 106..115; 415..417
Beta Strand
4..8; 14..22; 45..50; 53..60; 63..71; 172..185; 191..205; 207..209; 211..216; 245..248; 263..265; 269..279; 287..296; 300..309; 315..325; 330..345; 350..372; 386..394; 401..407; 409..412; 418..433
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Domain (FT)
170..434; MHD
Protein Families
Adaptor complexes medium subunit family
Sequence Similarities
Belongs to the adaptor complexes medium subunit family.
Clinical Relevance
Disease Involvement
Disease variantEpilepsyIntellectual disability
Interaction Protein
ENSG00000004975ENSG00000006125ENSG00000017797ENSG00000042753ENSG00000085832ENSG00000089818ENSG00000108309ENSG00000114416ENSG00000117597ENSG00000129245ENSG00000146648ENSG00000157191ENSG00000175416ENSG00000198925ENSG00000205726ENSG00000206560
Interaction Count
16
Interaction Dataset
intact_biogridintact_biogrid_opencellbiogrid_opencell