Protein detail

NTNG2

Netrin-G2 (Laminet-2)

Entry name NTNG2	UniProt ID Q96CW9	EVMP score 0.38
Frequency 3	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Netrin-G2 (Laminet-2)

Protein Class

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Predicted intracellular proteins

Ensembl

ENSG00000196358

Entrez Gene Symbol

NTNG2

Gene Synonym

KIAA1857Lmnt2NTNG1

Gene Description

Netrin G2

Chromosome

Position

132162058-132244526

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBrain excitatory neurons

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

35 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	Yes	No	No
adhesion	adhesion	OmniPath	Yes	Yes	Yes	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes	No	No
peripheral	peripheral	UniProt_location	No	No	Yes	No	No
peripheral	peripheral	OmniPath	No	No	Yes	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	Yes	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	Yes	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	No	No
secreted	secreted	connectomeDB2020	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NTNG2	Q96CW9	LRRC4	Q9HBW1	Yes	Yes	No	Fantom5_LRdbCellTalkDBiTALKtalklrRamilowski2015_Baccin2019SIGNORconnectomeDB2020HINTBaccin2019IntActLit-BM-17CellinkerLRdbSTRING_talklrEMBRACERamilowski2015	Lit-BM-17:21946559 LRdb:17973922 IntAct:21946559 Ramilowski2015:17973922 SIGNOR:19467332 HINT:21946559 connectomeDB2020:17973922 Cellinker:25411505 talklr:17973922 CellTalkDB:17973922

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	NTNG2	Q96CW9	2	PDB	PDB:3zyg
	LRRC4 NTNG2	Q96CW9 Q9HBW1	1:1	PDB	PDB:3zyi

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingELISA	4	24505114 37686366 40098346 31588238

Sequence, Structure & Domains

Sequences

Length

530

Mass

59,799

Sequence

MLHLLALFLHCLPLASGDYDICKSWVTTDEGPTWEFYACQPKVMRLKDYVKVKVEPSGITCGDPPERFCSHENPYLCSNECDASNPDLAHPPRLMFDKEEEGLATYWQSITWSRYPSPLEANITLSWNKTVELTDDVVMTFEYGRPTVMVLEKSLDNGRTWQPYQFYAEDCMEAFGMSARRARDMSSSSAHRVLCTEEYSRWAGSKKEKHVRFEVRDRFAIFAGPDLRNMDNLYTRLESAKGLKEFFTLTDLRMRLLRPALGGTYVQRENLYKYFYAISNIEVIGRCKCNLHANLCSMREGSLQCECEHNTTGPDCGKCKKNFRTRSWRAGSYLPLPHGSPNACATAGSFGNCECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNCNQIGSVHDRCNETGFCECREGAAGPKCDDCLPTHYWRQGCYPNVCDDDQLLCQNGGTCLQNQRCACPRGYTGVRCEQPRCDPADDDGGLDCDRAPGAAPRPATLLGCLLLLGLAARLGR

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96CW9-1; Sequence=Displayed; Name=2; IsoId=Q96CW9-2; Sequence=VSP_013147, VSP_013148

Alternative Sequence

352..422; NCECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNCNQIGSVHDRCN -> TLQTPPPGRSPSALRGSRRGLANVKEPAGSRPQISEMLLGCTVTLHQGSVGPHIPPKLSLPDPGGPWLGSQ (in isoform 2); 423..530; Missing (in isoform 2)

3D Structural Models

Turn

74..76; 86..88; 113..116; 198..204; 224..227; 336..338

Helix

46..49; 92..95; 171..175; 182..184; 187..189; 216..223; 230..239; 243..246; 271..273

Beta Strand

22..28; 31..36; 51..56; 66..68; 71..73; 79..81; 83..85; 107..109; 121..133; 137..143; 147..156; 162..170; 205..207; 210..213; 248..258; 277..282; 284..287; 296..299; 302..305; 311..313; 324..326

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Domain (CC)

The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains.

Domain (FT)

35..286; Laminin N-terminal; 287..346; Laminin EGF-like 1; 353..408; Laminin EGF-like 2; 409..453; Laminin EGF-like 3

Region

69..88; NGL discriminant loop I; 201..203; NGL discriminant loop II; 264..267; NGL discriminant loop III

Clinical Relevance

Disease Involvement

Autism spectrum disorderDisease variantIntellectual disability

Antibody

HPA024306 HPA071290