Protein detail
RHES
GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2)
Protein symbol RHES | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
MGC:4834RhesTEM2
Gene Description
RASD family member 2
Chromosome
22
Position
35540831-35553999
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineCell SpecificColonocytesSecretome LocationIntracellular and membraneSecretome FunctionDevelopmental protein
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| RASD2 | PRKACA | P17612 | S | 239 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KAPCA | P17612 | RHES | Q96D21 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:23999124 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
266
Mass
30,366
Sequence
MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVYNIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVDEMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSVNSDLKYIKAKVLREGQARERDKCTIQ
3D Structural Models
Domain & Motif Annotations
Motif
48..56; Effector region
Region
189..235; Interaction with GNB1, GNB2 and GNB3
Protein Families
- Small GTPase superfamily
- RasD family
Sequence Similarities
Belongs to the small GTPase superfamily. RasD family.
Clinical Relevance
Antibody