Protein detail
RHES
GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2)
Entry name RHES | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
MGC:4834RhesTEM2
Gene Description
RASD family member 2
Chromosome
22
Position
35540831-35553999
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificintestineCell SpecificColonocytesSecretome LocationIntracellular and membraneSecretome FunctionDevelopmental protein
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence9
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| RASD2 | PRKACA | P17612 | S | 239 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KAPCA | P17612 | RHES | Q96D21 | Yes | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:23999124 |
Sequence, Structure & Domains
Sequences
Length
266
Mass
30,366
Sequence
MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVYNIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVDEMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSVNSDLKYIKAKVLREGQARERDKCTIQ
Domain & Motif Annotations
Motif
48..56; Effector region
Region
189..235; Interaction with GNB1, GNB2 and GNB3
Protein Families (2)
- Small GTPase superfamily
- RasD family
Sequence Similarities
Belongs to the small GTPase superfamily. RasD family.
Clinical Relevance
Antibody
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 38037300 | Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles. | No related sentences available |
| 38576002 | Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation. | No related sentences available |