Protein detail

RHES

GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2)

Entry name RHES	UniProt ID Q96D21	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000100302

Entrez Gene Symbol

RASD2

Gene Synonym (3)

MGC:4834RhesTEM2

Gene Description

RASD family member 2

Chromosome

Position

35540831-35553999

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificintestineCell SpecificColonocytesSecretome LocationIntracellular and membraneSecretome FunctionDevelopmental protein

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence9

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
RASD2	PRKACA	P17612	S	239	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KAPCA	P17612	RHES	Q96D21	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:23999124

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	6	40985879 40189497 41068253 40730843 38207106 32854315

Sequence, Structure & Domains7

Sequences

Length

266

Mass

30,366

Sequence

MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVYNIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVDEMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSVNSDLKYIKAKVLREGQARERDKCTIQ

Domain & Motif Annotations

Motif

48..56; Effector region

Region

189..235; Interaction with GNB1, GNB2 and GNB3

Protein Families (2)

Small GTPase superfamily
RasD family

Sequence Similarities

Belongs to the small GTPase superfamily. RasD family.

Clinical Relevance1

Antibody

HPA005839

Supporting Publications2

PMID	Title	Abstract
38037300	Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.	No abstract available
38576002	Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation.	No abstract available