Protein detail
ORAI1
Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A)
Protein symbol ORAI1 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 4 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A)
Protein Class
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Potential drug targets
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Transporters:Transporter channels and pores
- Disease related genes
Transmembrane
88..105; Helical; 120..140; Helical; 174..194; Helical; 235..255; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
CRACM1FLJ14466TMEM142A
Gene Description
ORAI calcium release-activated calcium modulator 1
Chromosome
12
Position
121626509-121643218
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificMyonuclei
Function & Pathway
Protein Function
- Potential drug targets
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Transporters:Transporter channels and pores
- Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-983695 antigen activates b cell receptor bcr leading to generation of second messengers
- R-hsa-5576891 cardiac conduction
- R-hsa-139853 elevation of cytosolic ca2 levels
- R-hsa-109582 hemostasis
- R-hsa-5578775 ion homeostasis
- R-hsa-397014 muscle contraction
- R-hsa-418360 platelet calcium homeostasis
- R-hsa-418346 platelet homeostasis
- R-hsa-983705 signaling by the b cell receptor bcr
Mediation Categories
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ORAI1 | PRKCB | P05771 | S | 30 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:20534587ProtMapper:20534587 |
| ORAI1 | PRKCB | P05771 | S | 27 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:20534587ProtMapper:20534587ProtMapper:23052215 |
| ORAI1 | PRKACA | P17612 | S | 34 | phosphorylation | PhosphoSite | |
| ORAI1 | PRKG1 | Q13976 | S | 34 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCB | P05771 | ORAI1 | Q96D31 | Yes | No | Yes | PhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:23454861ProtMapper:23052215SIGNOR:20534587PhosphoSite:20534587ProtMapper:23890116PhosphoSite:23144458ProtMapper:20534587 |
| KAPCA | P17612 | ORAI1 | Q96D31 | Yes | Yes | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:26269433PhosphoSite:31036819PhosphoSite:31652779 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometryAntibody array|Mass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF]Small R sequencing (Illumi HiSeq 2000 (Solexa) | 10 | 34186243311969683303581438168906289865852789410430646616337095103208974333709510 |
Sequence, Structure & Domains
Sequences
Length
301
Mass
32,668
Sequence
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
Alternative Products
Event=Alternative initiation; Named isoforms=2; Name=alpha; IsoId=Q96D31-1; Sequence=Displayed; Name=beta; IsoId=Q96D31-2; Sequence=VSP_044421
Alternative Sequence
1..70; Missing (in isoform beta)
3D Structural Models
Helix
76..86; 272..288
3D Structure
NMR spectroscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
1..17; Pro residues; 18..27; Low complexity
Domain (CC)
The Pro-rich region of ORAI1 (residues 3-47) functionally interacts with the polybasic Lys-rich region of STIM1 (residues 672-685) and regulates CRAC channel gating at negative membrane potentials.; DOMAIN: [Isoform alpha]: AKAP5 association region (AKAR) mediates coupling of ORAI1 to AKAP5-dependent NFATC2/NFAT1 transcriptional responses.
Region
1..51; Disordered; 3..47; Required for generation of inwardly rectifying CRAC currents; 39..59; AKAP5 association region; 70..90; Interaction with STIM1; 205..225; Disordered; 272..292; Interaction with STIM1
Protein Families
Orai family
Sequence Similarities
Belongs to the Orai family.