Protein detail

REPS1

RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)

Entry name REPS1	UniProt ID Q96D71	EVMP confidence score 0.50
Supporting publications (n) 5	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000135597

Entrez Gene Symbol

REPS1

Gene Description

RALBP1 associated Eps domain containing 1

Chromosome

Position

138903493-138988261

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Cell SpecificEndometrial ciliated cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway7

Protein Function (3)

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

Reactome (4)

Canonical Pathways (3)

M31 Pid beta catenin deg pathway
M219 Pid hedgehog gli pathway
M136 Pid foxo pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence6

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
REPS1	RPS6KA1	Q15418	S	709	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Rab11-Fip2-Reps1 complex	RAB11FIP2 REPS1	Q7L804 Q96D71	1:1	Compleat	Compleat:HC3607	12364336

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	31414377

Sequence, Structure & Domains9

Sequences

Length

796

Mass

86,662

Sequence

MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDSENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96D71-1; Sequence=Displayed; Name=2; IsoId=Q96D71-2; Sequence=VSP_007953, VSP_007954; Name=3; IsoId=Q96D71-3; Sequence=VSP_007955; Name=4; IsoId=Q96D71-4; Sequence=VSP_007953

Alternative Sequence

420..446; Missing (in isoform 2 and isoform 4); 510..573; Missing (in isoform 2); 510; Missing (in isoform 3)

Domain & Motif Annotations

Compositional Bias

115..126; Polar residues; 145..156; Polar residues; 407..433; Polar residues; 506..543; Polar residues; 544..554; Pro residues; 563..574; Polar residues; 575..584; Low complexity; 585..596; Pro residues; 612..623; Polar residues; 671..681; Basic and acidic residues; 708..722; Basic and acidic residues

Coiled Coil

751..791

Domain (FT)

10..113; EH 1; 285..374; EH 2; 318..353; EF-hand

Region

105..237; Disordered; 377..433; Disordered; 506..624; Disordered; 638..725; Disordered; 652..796; Interaction with RALBP1

Clinical Relevance5

Disease Involvement (2)

Disease variantNeurodegeneration

Antibody (3)

HPA029961 HPA029962 HPA029963

Interaction Protein

ENSG00000017797

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications5

PMID	Title	Abstract
27821849	Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.	No abstract available
32230970	Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.	No abstract available
33592500	A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No abstract available