Protein detail
REPS1
RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)
Protein symbol REPS1 | UniProt ID | EVMP score 0.50 |
Frequency 5 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
Basic Information
Protein Names
RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
RALBP1 associated Eps domain containing 1
Chromosome
6
Position
138903493-138988261
Frequency
5
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEndometrial ciliated cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M31 Pid beta catenin deg pathway
- M219 Pid hedgehog gli pathway
- M136 Pid foxo pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| REPS1 | RPS6KA1 | Q15418 | S | 709 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 31414377 |
Sequence, Structure & Domains
Sequences
Length
796
Mass
86,662
Sequence
MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDSENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96D71-1; Sequence=Displayed; Name=2; IsoId=Q96D71-2; Sequence=VSP_007953, VSP_007954; Name=3; IsoId=Q96D71-3; Sequence=VSP_007955; Name=4; IsoId=Q96D71-4; Sequence=VSP_007953
Alternative Sequence
420..446; Missing (in isoform 2 and isoform 4); 510..573; Missing (in isoform 2); 510; Missing (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
115..126; Polar residues; 145..156; Polar residues; 407..433; Polar residues; 506..543; Polar residues; 544..554; Pro residues; 563..574; Polar residues; 575..584; Low complexity; 585..596; Pro residues; 612..623; Polar residues; 671..681; Basic and acidic residues; 708..722; Basic and acidic residues
Coiled Coil
751..791
Domain (FT)
10..113; EH 1; 285..374; EH 2; 318..353; EF-hand
Region
105..237; Disordered; 377..433; Disordered; 506..624; Disordered; 638..725; Disordered; 652..796; Interaction with RALBP1