Protein detail
HVCN1
Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) (Voltage sensor domain-only protein)
Protein symbol HVCN1 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 4 | Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) (Voltage sensor domain-only protein)
Protein Class
Predicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Transmembrane
101..121; Helical; Name=Segment S1; 139..161; Helical; Name=Segment S2; 170..190; Helical; Name=Segment S3; 198..218; Helical; Name=Segment S4
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
Hv1MGC15619VSOP
Gene Description
Hydrogen voltage gated channel 1
Chromosome
12
Position
110627841-110704950
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificpancreasCell SpecificEarly spermatids
Function & Pathway
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| HVCN1 | PRKCD | Q05655 | S | 77 | phosphorylation | PhosphoSite | |
| HVCN1 | PRKCD | Q05655 | T | 9 | phosphorylation | PhosphoSite | |
| HVCN1 | PRKCD | Q05655 | T | 29 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| HVCN1 | PRKCD | Q05655 | S | 97 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCD | Q05655 | HVCN1 | Q96D96 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:25425665PhosphoSite:20037153PhosphoSite:25425665 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 22 | 34186243322958332914823927863537311969683303581435611462377869183816890640748658394090153481790628986585263789402789410428590090306466163095018532166700383215353519496532089743 |
Sequence, Structure & Domains
Sequences
Length
273
Mass
31,683
Sequence
MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96D96-1; Sequence=Displayed; Name=2; IsoId=Q96D96-2; Sequence=VSP_034395; Name=3; IsoId=Q96D96-3; Sequence=VSP_034396; Name=4; IsoId=Q96D96-4; Sequence=VSP_045052
Alternative Sequence
1..20; Missing (in isoform 4); 66..102; Missing (in isoform 2); 253..273; EQEIERLNKLLRQHGLLGEVN -> PLD (in isoform 3)
3D Structural Models
Helix
87..99; 101..124; 134..157; 169..189; 197..223; 227..265
Beta Strand
163..166; 190..193
3D Structure
NMR spectroscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
47..56; Acidic residues
Coiled Coil
223..266
Domain (CC)
The voltage sensor domain (VSD, segments S1-S4) conducts both gating and ion permeation. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain.; DOMAIN: The C-terminal coiled coil region mediates homodimerization and cooperative channel gating. It is essential for normal subcellular localization.
Region
46..80; Disordered
Protein Families
Voltage-gated proton channel (VPC) (TC 1.A.51) family
Sequence Similarities
Belongs to the voltage-gated proton channel (VPC) (TC 1.A.51) family.
Clinical Relevance
Antibody