Protein detail

KLRG1

Killer cell lectin-like receptor subfamily G member 1 (C-type lectin domain family 15 member A) (ITIM-containing receptor MAFA-L) (MAFA-like receptor) (Mast cell function-associated antigen)

Entry name KLRG1	UniProt ID Q96E93	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Killer cell lectin-like receptor subfamily G member 1 (C-type lectin domain family 15 member A) (ITIM-containing receptor MAFA-L) (MAFA-like receptor) (Mast cell function-associated antigen)

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

39..59; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000139187

Entrez Gene Symbol

KLRG1

Gene Synonym (4)

2F1CLEC15AMAFAMAFA-L

Gene Description

Killer cell lectin like receptor G1

Chromosome

Position

8950044-9010760

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Blood Cell Specificnaive B-cell

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

Reactome (2)

Mediation Categories (2)

Clinical-translation mediationImmune mediation

Relations & Evidence53

Ligand-Receptor Signaling (52)

52 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
immune_cell	receptor	HPMR	No	Yes	No	Yes	No
killer_cell_lectin_like_receptor_immune_cell	receptor	HPMR	No	Yes	No	Yes	No
class_e	receptor	Surfaceome	No	Yes	No	Yes	No
scar	receptor	Surfaceome	No	Yes	No	Yes	No
cell_adhesion	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Small R sequencing (Illumi HiSeq 2000 (Solexa)Mass spectrometry	7	39873726 32795414 38731868 33709510 38321535 41201090 30760538

Sequence, Structure & Domains12

Sequences

Length

195

Mass

21,831

Sequence

MTDSVIYSMLELPTATQAQNDYGPQQKSSSSRPSCSCLVAIALGLLTAVLLSVLLYQWILCQGSNYSTCASCPSCPDRWMKYGNHCYYFSVEEKDWNSSLEFCLARDSHLLVITDNQEMSLLQVFLSEAFCWIGLRNNSGWRWEDGSPLNFSRISSNSFVQTCGAINKNGLQASSCEVPLHWVCKKCPFADQALF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96E93-1; Sequence=Displayed; Name=2; IsoId=Q96E93-2; Sequence=VSP_033151

Alternative Sequence

187..195; CPFADQALF -> VRL (in isoform 2)

3D Structural Models

Turn

105..107

Helix

96..104; 116..123

Beta Strand

80..82; 85..89; 131..143; 163..167; 170..174; 180..185

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Motif

5..10; ITIM motif

Domain (CC)

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D (By similarity).

Domain (FT)

82..185; C-type lectin

Clinical Relevance3

Related Diseases

Idiopathic inflammatory myopathy

Biomarker

Phase 2/3

Antibody (2)

HPA051403 HPA076494

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available