Protein detail
KLRG1
Killer cell lectin-like receptor subfamily G member 1 (C-type lectin domain family 15 member A) (ITIM-containing receptor MAFA-L) (MAFA-like receptor) (Mast cell function-associated antigen)
Entry name KLRG1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Killer cell lectin-like receptor subfamily G member 1 (C-type lectin domain family 15 member A) (ITIM-containing receptor MAFA-L) (MAFA-like receptor) (Mast cell function-associated antigen)
Protein Class (2)
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
39..59; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
2F1CLEC15AMAFAMAFA-L
Gene Description
Killer cell lectin like receptor G1
Chromosome
12
Position
8950044-9010760
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Blood Cell Specificnaive B-cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Reactome (2)
Mediation Categories (2)
Clinical-translation mediationImmune mediation
Relations & Evidence53
Ligand-Receptor Signaling (52)
52 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| immune_cell | receptor | HPMR | Yes | Yes | |||
| killer_cell_lectin_like_receptor_immune_cell | receptor | HPMR | Yes | Yes | |||
| class_e | receptor | Surfaceome | Yes | Yes | |||
| scar | receptor | Surfaceome | Yes | Yes | |||
| cell_adhesion | receptor | ICELLNET | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| extracellular | extracellular | HPMR | Yes | ||||
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | LOCATE | Yes | ||||
| intracellular | intracellular | ComPPI | Yes |
Isolation & Detection Technology (1)
Sequence, Structure & Domains
Sequences
Length
195
Mass
21,831
Sequence
MTDSVIYSMLELPTATQAQNDYGPQQKSSSSRPSCSCLVAIALGLLTAVLLSVLLYQWILCQGSNYSTCASCPSCPDRWMKYGNHCYYFSVEEKDWNSSLEFCLARDSHLLVITDNQEMSLLQVFLSEAFCWIGLRNNSGWRWEDGSPLNFSRISSNSFVQTCGAINKNGLQASSCEVPLHWVCKKCPFADQALF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96E93-1; Sequence=Displayed; Name=2; IsoId=Q96E93-2; Sequence=VSP_033151
Alternative Sequence
187..195; CPFADQALF -> VRL (in isoform 2)
3D Structural Models
Turn
105..107
Helix
96..104; 116..123
Beta Strand
80..82; 85..89; 131..143; 163..167; 170..174; 180..185
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Motif
5..10; ITIM motif
Domain (CC)
Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D (By similarity).
Domain (FT)
82..185; C-type lectin
Clinical Relevance
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No related sentences available |