Protein detail
LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A)
Protein symbol LIGO1 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A)
Protein Class
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Transmembrane
562..582; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ14594LERN1LRRN6A
Gene Description
Leucine rich repeat and Ig domain containing 1
Chromosome
15
Position
77613027-77820900
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificCorticotrophs
Function & Pathway
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Cellular Component
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
46 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | Cellinker | No | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| OMGP | P23515 | LIGO1 | Q96FE5 | Yes | Yes | No | HPMRFantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr | connectomeDB2020:14966521SIGNOR:15694321Cellinker:14966521CellTalkDB:14966521HPMR:14966521LRdb:14966521 |
| RTN4 | Q9NQC3 | LIGO1 | Q96FE5 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019WangLRdbEMBRACEHPMR_talklr | CellTalkDB:15694322SIGNOR:15694321connectomeDB2020:15694322LRdb:15694322Baccin2019:15694322 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry | 12 | 341862433303581439766158363985643778691839505756377027153481790628986585278941043832153532089743 |
Sequence, Structure & Domains
Sequences
Length
620
Mass
69,876
Sequence
MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96FE5-1; Sequence=Displayed; Name=2; IsoId=Q96FE5-2; Sequence=VSP_032749
Alternative Sequence
1..6; Missing (in isoform 2)
3D Structural Models
Turn
50..53; 88..93; 112..117; 160..165; 257..262; 328..330; 382..385; 416..419
Helix
208..211; 280..283; 352..354; 358..360; 375..377; 378..381; 400..402; 407..409; 489..491
Beta Strand
47..49; 54..56; 74..77; 99..101; 123..125; 147..149; 171..174; 195..200; 219..224; 243..247; 266..273; 291..293; 315..317; 324..326; 339..341; 363..365; 395..399; 422..427; 432..437; 442..444; 448..452; 455..459; 472..476; 482..486; 493..501; 504..515
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Repeat
72..93; LRR 1; 96..117; LRR 2; 120..141; LRR 3; 144..165; LRR 4; 168..189; LRR 5; 192..213; LRR 6; 216..237; LRR 7; 264..285; LRR 8; 288..309; LRR 9; 312..333; LRR 10; 336..357; LRR 11
Domain (CC)
The intracellular domain of LINGO1 interacts with MYT1L.
Domain (FT)
42..71; LRRNT; 369..423; LRRCT; 411..513; Ig-like C2-type
Clinical Relevance
Disease Involvement
Disease variantIntellectual disability
Related Diseases
Biomarker
Phase 2
Drugs
Antibody