Protein detail

LIGO1

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A)

Entry name LIGO1	UniProt ID Q96FE5	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein Class (6)

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (5)

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Transmembrane

562..582; Helical

Transmembrane Count

Ensembl

ENSG00000169783

Entrez Gene Symbol

LINGO1

Gene Synonym (3)

FLJ14594LERN1LRRN6A

Gene Description

Leucine rich repeat and Ig domain containing 1

Chromosome

Position

77613027-77820900

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificCorticotrophs

Function & Pathway6

Protein Function (5)

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

Reactome (3)

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence52

Ligand-Receptor Signaling (46)

46 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	Baccin2019	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
OMGP	P23515	LIGO1	Q96FE5	Yes	Yes	No	HPMRFantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr	connectomeDB2020:14966521 SIGNOR:15694321 Cellinker:14966521 CellTalkDB:14966521 HPMR:14966521 LRdb:14966521
RTN4	Q9NQC3	LIGO1	Q96FE5	Yes	Yes	No	Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019WangLRdbEMBRACEHPMR_talklr	CellTalkDB:15694322 SIGNOR:15694321 connectomeDB2020:15694322 LRdb:15694322 Baccin2019:15694322

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
LINGO1 Q6PIL8 S6B291	Q6PIL8 Q96FE5 S6B291	1:1:1	PDB	PDB:4oqt
LINGO1 LINGO2	Q7L985 Q96FE5	0:0	hu.MAP2
LINGO1	Q96FE5	4	PDB	PDB:2id5

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	12	34186243 33035814 39766158 36398564 37786918 39505756 37702715 34817906 28986585 27894104 38321535 32089743

Sequence, Structure & Domains12

Sequences

Length

620

Mass

69,876

Sequence

MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96FE5-1; Sequence=Displayed; Name=2; IsoId=Q96FE5-2; Sequence=VSP_032749

Alternative Sequence

1..6; Missing (in isoform 2)

3D Structural Models

Turn

50..53; 88..93; 112..117; 160..165; 257..262; 328..330; 382..385; 416..419

Helix

208..211; 280..283; 352..354; 358..360; 375..377; 378..381; 400..402; 407..409; 489..491

Beta Strand

47..49; 54..56; 74..77; 99..101; 123..125; 147..149; 171..174; 195..200; 219..224; 243..247; 266..273; 291..293; 315..317; 324..326; 339..341; 363..365; 395..399; 422..427; 432..437; 442..444; 448..452; 455..459; 472..476; 482..486; 493..501; 504..515

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Repeat

72..93; LRR 1; 96..117; LRR 2; 120..141; LRR 3; 144..165; LRR 4; 168..189; LRR 5; 192..213; LRR 6; 216..237; LRR 7; 264..285; LRR 8; 288..309; LRR 9; 312..333; LRR 10; 336..357; LRR 11

Domain (CC)

The intracellular domain of LINGO1 interacts with MYT1L.

Domain (FT)

42..71; LRRNT; 369..423; LRRCT; 411..513; Ig-like C2-type

Clinical Relevance5

Disease Involvement (2)

Disease variantIntellectual disability

Related Diseases

Multiple sclerosis

Biomarker

Phase 2

Drugs

OPICINUMAB

Antibody

HPA074653

Supporting Publications2

PMID	Title	Abstract
36842607	Serum Exosomes From Epithelial Ovarian Cancer Patients Contain LRP1, Which Promotes the Migration of Epithelial Ovarian Cancer Cell.	No abstract available
37368488	An LRP1-binding motif in cellular prion protein replicates cell-signaling activities of the full-length protein.	Low-density lipoprotein receptor-related protein-1 (LRP1) functions as a receptor for nonpathogenic cellular prion protein (PrPC), which is released from cells by ADAM (a disintegrin and metalloproteinase domain) proteases or in extracellular vesicles.