Protein detail

STALP

AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1)

Entry name STALP	UniProt ID Q96FJ0	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1)

Protein Class (3)

EnzymesMetabolic proteinsPredicted intracellular proteins

Protein Function (3)

Peptidases:Metallopeptidases
Enzymes
Predicted intracellular proteins

Ensembl

ENSG00000138134

Entrez Gene Symbol

STAMBPL1

Gene Synonym (6)

ALMalphaAMSH-FPAMSH-LPbA399O19.2FLJ31524KIAA1373

Gene Description

STAM binding protein like 1

Chromosome

Position

88879734-88975153

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificNeutrophils

Function & Pathway5

Protein Function (3)

Peptidases:Metallopeptidases
Enzymes
Predicted intracellular proteins

Cellular Component (3)

Molecular Function (4)

Reactome (3)

Mediation Categories

Other mediation

Relations & Evidence6

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CLTCL1 PICALM STAMBPL1	P53675 Q13492 Q96FJ0	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation	Western blotting	1	38731868

Sequence, Structure & Domains14

Sequences

Length

436

Mass

49,783

Sequence

MDQPFTVNSLKKLAAMPDHTDVSLSPEERVRALSKLGCNITISEDITPRRYFRSGVEMERMASVYLEEGNLENAFVLYNKFITLFVEKLPNHRDYQQCAVPEKQDIMKKLKEIAFPRTDELKNDLLKKYNVEYQEYLQSKNKYKAEILKKLEHQRLIEAERKRIAQMRQQQLESEQFLFFEDQLKKQELARGQMRSQQTSGLSEQIDGSALSCFSTHQNNSLLNVFADQPNKSDATNYASHSPPVNRALTPAATLSAVQNLVVEGLRCVVLPEDLCHKFLQLAESNTVRGIETCGILCGKLTHNEFTITHVIVPKQSAGPDYCDMENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSSVDLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTNAGMLEVSACKKKGFHPHTKEPRLFSICKHVLVKDIKIIVLDLR

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96FJ0-1; Sequence=Displayed; Name=2; IsoId=Q96FJ0-2; Sequence=VSP_014648

Alternative Sequence

420..436; CKHVLVKDIKIIVLDLR -> QKFLSGIISGTALEMEPLKIGYGPNGFPLLGISRSSSPSEQL (in isoform 2)

3D Structural Models

Turn

288..290

Helix

275..287; 328..338; 358..370; 381..383; 393..401

Beta Strand

269..272; 294..302; 305..313; 316..319; 322..325; 341..348; 350..352; 375..380; 385..391; 416..419; 421..426; 431..434

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Motif

347..360; JAMM motif

Domain (CC)

The JAMM motif is essential for the protease activity.

Domain (FT)

269..397; MPN

Protein Families

Peptidase M67C family

Sequence Similarities

Belongs to the peptidase M67C family.

Clinical Relevance4

Antibody

HPA040202

Interaction Protein (2)

ENSG00000105982ENSG00000221867

Interaction Count

Interaction Dataset (2)

intact_biogridintact_biogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
40689422	Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles.	No abstract available