Protein detail
PGAP3
GPI-specific phospholipase A2-like PGAP3 (EC 3.1.1.-) (COS16 homolog) (hCOS16) (Gene coamplified with ERBB2 protein) (PER1-like domain-containing protein 1) (Post-GPI attachment to proteins factor 3)
Protein symbol PGAP3 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 7 | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
GPI-specific phospholipase A2-like PGAP3 (EC 3.1.1.-) (COS16 homolog) (hCOS16) (Gene coamplified with ERBB2 protein) (PER1-like domain-containing protein 1) (Post-GPI attachment to proteins factor 3)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Predicted intracellular proteins
Transmembrane
99..119; Helical; 136..156; Helical; 170..190; Helical; 194..214; Helical; 225..245; Helical; 258..278; Helical; 280..299; Helical
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
CAB2MGC9753PER1PERLD1PP1498
Gene Description
Post-GPI attachment to proteins phospholipase 3
Chromosome
17
Position
39671122-39696797
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificMyonuclei
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Predicted intracellular proteins
Cellular Component
Biological Process
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blottingFlow cytometry | 1 | 38321535 |
Sequence, Structure & Domains
Sequences
Length
320
Mass
36,475
Sequence
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLAGWTCRDDCKYECMWVTVGLYLQEGHKVPQFHGKWPFSRFLFFQEPASAVASFLNGLASLVMLCRYRTFVPASSPMYHTCVAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASTVILHSIYLCCVRTVGLQHPAVVSAFRALLLLMLTVHVSYLSLIRFDYGYNLVANVAIGLVNVVWWLAWCLWNQRRLPHVRKCVVVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFSFLEDDSLYLLKESEDKFKLD
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96FM1-1; Sequence=Displayed; Name=2; IsoId=Q96FM1-2; Sequence=VSP_034158; Name=3; IsoId=Q96FM1-3; Sequence=VSP_057229
Alternative Sequence
94..144; Missing (in isoform 2); 145..165; Missing (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Protein Families
PGAP3 family
Sequence Similarities
Belongs to the PGAP3 family.
Clinical Relevance
Disease Involvement
Disease variantIntellectual disability
Antibody