Protein detail

LRC46

Leucine-rich repeat-containing protein 46

Entry name LRC46	UniProt ID Q96FV0	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Leucine-rich repeat-containing protein 46

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000141294

Entrez Gene Symbol

LRRC46

Gene Synonym

MGC16309

Gene Description

Leucine rich repeat containing 46

Chromosome

Position

47831634-47837719

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Tissue SpecifictestisCell SpecificEarly spermatids

Function & Pathway3

Protein Function

Predicted intracellular proteins

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	6	40985879 40465195 37322475 40189497 30915084 38207106

Sequence, Structure & Domains7

Sequences

Length

321

Mass

35,340

Sequence

MSGGKSAQGPEEGGVCITEALITKRNLTFPEDGELSEKMFHTLDELQTVRLDREGITTIRNLEGLQNLHSLYLQGNKIQQIENLACIPSLRFLSLAGNQIRQVENLLDLPCLQFLDLSENLIETLKLDEFPQSLLILNLSGNSCTNQDGYRELVTEALPLLLDLDGQPVVERWISDEEDEASSDEEFPELSGPFCSERGFLKELEQELSRHREHRQQTALTEHLLRMEMQPTLTDLPLLPGVPMAGDSSPSATPAQGEETVPEAVSSPQASSPTKKPCSLIPRGHQSSFWGRKGARAATAPKASVAEAPSTTKTTAKRSKK

Domain & Motif Annotations

Repeat

45..66; LRR 1; 67..88; LRR 2; 89..110; LRR 3; 111..132; LRR 4

Coiled Coil

201..221

Domain (FT)

142..184; LRRCT

Region

235..321; Disordered

Clinical Relevance1

Antibody

HPA074893

Supporting Publications1

PMID	Title	Abstract
22329422	Quantitative proteome profiling of normal human circulating microparticles.	No abstract available