Protein detail
TIMD4
T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD-4) (T-cell immunoglobulin mucin receptor 4) (TIM-4) (T-cell membrane protein 4)
Protein symbol TIMD4 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD-4) (T-cell immunoglobulin mucin receptor 4) (TIM-4) (T-cell membrane protein 4)
Protein Class
Plasma proteinsPredicted membrane proteins
Transmembrane
315..335; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
TIM4
Gene Description
T cell immunoglobulin and mucin domain containing 4
Chromosome
5
Position
156919292-156963226
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
M117 Pid cone pathway
Mediation Categories
Clinical-translation mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
30 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | Yes | Yes | No |
| ecm | ecm | OmniPath | Yes | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | Yes | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Ultrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 41063451 |
Sequence, Structure & Domains
Sequences
Length
378
Mass
41,578
Sequence
MSKEPLILWLMIEFWWLYLTPVTSETVVTEVLGHRVTLPCLYSSWSHNSNSMCWGKDQCPYSGCKEALIRTDGMRVTSRKSAKYRLQGTIPRGDVSLTILNPSESDSGVYCCRIEVPGWFNDVKINVRLNLQRASTTTHRTATTTTRRTTTTSPTTTRQMTTTPAALPTTVVTTPDLTTGTPLQMTTIAVFTTANTCLSLTPSTLPEEATGLLTPEPSKEGPILTAESETVLPSDSWSSVESTSADTVLLTSKESKVWDLPSTSHVSMWKTSDSVSSPQPGASDTAVPEQNKTTKTGQMDGIPMSMKNEMPISQLLMIIAPSLGFVLFALFVAFLLRGKLMETYCSQKHTRLDYIGDSKNVLNDVQHGREDEDGLFTL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96H15-1; Sequence=Displayed; Name=2; IsoId=Q96H15-2; Sequence=VSP_045474
Alternative Sequence
254..281; Missing (in isoform 2)
3D Structural Models
Turn
47..49
Helix
90..92; 104..106
Beta Strand
25..31; 36..38; 51..58; 68..71; 73..81; 84..86; 97..101; 108..115; 117..120; 123..133
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
269..297; Polar residues
Domain (CC)
Recognizes phosphatidyl serine via its immunoglobulin domain.
Domain (FT)
25..126; Ig-like V-type
Region
136..160; Disordered; 269..304; Disordered
Protein Families
- Immunoglobulin superfamily
- TIM family
Sequence Similarities
Belongs to the immunoglobulin superfamily. TIM family.