Protein detail
TIMD4
T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD-4) (T-cell immunoglobulin mucin receptor 4) (TIM-4) (T-cell membrane protein 4)
Entry name TIMD4 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD-4) (T-cell immunoglobulin mucin receptor 4) (TIM-4) (T-cell membrane protein 4)
Protein Class (2)
Plasma proteinsPredicted membrane proteins
Transmembrane
315..335; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
TIM4
Gene Description
T cell immunoglobulin and mucin domain containing 4
Chromosome
5
Position
156919292-156963226
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization5
Cell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway7
Cellular Component (2)
Molecular Function
Biological Process (3)
Reactome (4)
Canonical Pathways
M117 Pid cone pathway
Mediation Categories (2)
Clinical-translation mediationImmune mediation
Relations & Evidence32
Ligand-Receptor Signaling (30)
30 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | UniProt_keyword | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_location | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Ultrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 41063451 |
Sequence, Structure & Domains15
Sequences
Length
378
Mass
41,578
Sequence
MSKEPLILWLMIEFWWLYLTPVTSETVVTEVLGHRVTLPCLYSSWSHNSNSMCWGKDQCPYSGCKEALIRTDGMRVTSRKSAKYRLQGTIPRGDVSLTILNPSESDSGVYCCRIEVPGWFNDVKINVRLNLQRASTTTHRTATTTTRRTTTTSPTTTRQMTTTPAALPTTVVTTPDLTTGTPLQMTTIAVFTTANTCLSLTPSTLPEEATGLLTPEPSKEGPILTAESETVLPSDSWSSVESTSADTVLLTSKESKVWDLPSTSHVSMWKTSDSVSSPQPGASDTAVPEQNKTTKTGQMDGIPMSMKNEMPISQLLMIIAPSLGFVLFALFVAFLLRGKLMETYCSQKHTRLDYIGDSKNVLNDVQHGREDEDGLFTL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96H15-1; Sequence=Displayed; Name=2; IsoId=Q96H15-2; Sequence=VSP_045474
Alternative Sequence
254..281; Missing (in isoform 2)
3D Structural Models
Turn
47..49
Helix
90..92; 104..106
Beta Strand
25..31; 36..38; 51..58; 68..71; 73..81; 84..86; 97..101; 108..115; 117..120; 123..133
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
269..297; Polar residues
Domain (CC)
Recognizes phosphatidyl serine via its immunoglobulin domain.
Domain (FT)
25..126; Ig-like V-type
Region
136..160; Disordered; 269..304; Disordered
Protein Families (2)
- Immunoglobulin superfamily
- TIM family
Sequence Similarities
Belongs to the immunoglobulin superfamily. TIM family.