Protein detail

PDLI5

PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)

Entry name PDLI5	UniProt ID Q96HC4	EVMP confidence score 0.60
Supporting publications (n) 18	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)

Protein Class (3)

Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000163110

Entrez Gene Symbol

PDLIM5

Gene Synonym (2)

EnhLIM

Gene Description

PDZ and LIM domain 5

Chromosome

Position

94451857-94668227

Supporting publications (n)

EVMP confidence score

0.60

Fluorescence & Localization2

Cell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specificastrocyte

Function & Pathway7

Protein Function

Predicted intracellular proteins

Cellular Component (10)

Molecular Function (7)

Biological Process (3)

KEGG

hsa04820 Cytoskeleton in muscle cells

Reactome (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence22

Enzyme-Mediated Modification (7)

7 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
PDLIM5	MAPK6	Q16659	S	111	phosphorylation	PhosphoNetworks
PDLIM5	MAPK6	Q16659	S	137	phosphorylation	PhosphoNetworks
PDLIM5	MAPK6	Q16659	S	313	phosphorylation	PhosphoNetworks
PDLIM5	MAPK6	Q16659	S	360	phosphorylation	PhosphoNetworks
PDLIM5	MAPK6	Q16659	T	417	phosphorylation	PhosphoNetworks
PDLIM5	PDPK1	O15530	S	137	phosphorylation	PhosphoNetworks
PDLIM5	PDPK1	O15530	S	319	phosphorylation	PhosphoNetworks

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (9)

9 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ACADSB ALAD CZIB DUS3L PDLIM5 RASA1 SARS1	P13716 P20936 P45954 P49591 Q96G46 Q96HC4 Q9NWV4	0:0:0:0:0:0:0	hu.MAP
FKBP1A PDLIM5 SUMO3 TAGLN2 TAGLN3	P37802 P55854 P62942 Q96HC4 Q9UI15	0:0:0:0:0	hu.MAP2
MKNK1 PDLIM5 TTC3	P53804 Q96HC4 Q9BUB5	0:0:0	hu.MAP
DNAJB12 MKNK1 PDLIM5 TTC3	P53804 Q96HC4 Q9BUB5 Q9NXW2	0:0:0:0	hu.MAP
CNN3 PDLIM5 RWDD2B	P57060 Q15417 Q96HC4	0:0:0	hu.MAP2
PDLIM5 RWDD2B	P57060 Q96HC4	0:0	hu.MAP2
CNN3 PDLIM5	Q15417 Q96HC4	0:0	hu.MAP2
PDLIM5	Q96HC4	5	PDB	PDB:2uzc
MKNK1 PDLIM5	Q96HC4 Q9BUB5	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	7	38037300 40689422 34265469 38576002 37403840 39996590 36573687

Sequence, Structure & Domains12

Sequences

Length

596

Mass

63,945

Sequence

MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q96HC4-1; Sequence=Displayed; Name=2; IsoId=Q96HC4-2; Sequence=VSP_039075, VSP_039076, VSP_039077, VSP_039078; Name=3; IsoId=Q96HC4-3; Sequence=VSP_039206, VSP_039207, VSP_039077, VSP_039078; Name=4; IsoId=Q96HC4-4; Sequence=VSP_039075; Name=5; IsoId=Q96HC4-5; Sequence=VSP_045098, VSP_045099; Name=6; IsoId=Q96HC4-6; Sequence=VSP_039075, VSP_039076, VSP_053796; Name=7; IsoId=Q96HC4-7; Sequence=VSP_039075, VSP_039076, VSP_053797

Alternative Sequence

33..136; LKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVS -> AGVQWRNLGSPQPPSPEFKRFSCLSLPSSWDYRHVPPRLANFVFLVETKFPYVGQAGLELPTSGDLPTSASQSAKITGVSHRAWPTLFYTLLFFATIYPEIILY (in isoform 5); 98..206; Missing (in isoform 2, isoform 4, isoform 6 and isoform 7); 98..117; GEPKEVVKPVPITSPAVSKV -> KTQVTNNPGTVKIPPKRPPR (in isoform 3); 118..240; Missing (in isoform 3); 137..596; Missing (in isoform 5); 237; G -> GKIPPKR (in isoform 2, isoform 6 and isoform 7); 307..337; NNSQEPSPQLASSVASTRSMPESLDSPTSGR -> KEKIPLHVFSPKYTKLRDWHHEVSARALNVQ (in isoform 2 and isoform 3); 307; N -> KFDSALEDLPKSGPHPPATPQVLTIGSQVATLSKVATTYSSLSSSTGNVEDSFEGFRNFSTFSSPARYSAAVLSSAAATVSAVIATKTRLYTPERYHSLLDALCISPVSKPLAFSYLQSSRKSTGSIHVKKTS (in isoform 6); 338..596; Missing (in isoform 2 and isoform 3); 587..596; Missing (in isoform 7)

3D Structural Models

Turn

413..415; 441..443

Helix

22..24; 38..41; 63..71; 468..474

Beta Strand

3..12; 16..21; 26..33; 49..53; 75..82; 409..411; 419..423; 431..434; 437..439; 447..449; 454..456; 458..463

3D Structure

NMR spectroscopy (1); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

134..143; Polar residues; 144..165; Low complexity; 205..219; Polar residues; 226..237; Polar residues; 258..273; Basic and acidic residues; 293..304; Basic and acidic residues; 305..335; Polar residues; 361..381; Polar residues

Domain (FT)

2..85; PDZ; 418..477; LIM zinc-binding 1; 477..536; LIM zinc-binding 2; 536..596; LIM zinc-binding 3

Region

121..165; Disordered; 196..240; Disordered; 255..340; Disordered; 354..381; Disordered

Clinical Relevance4

Antibody (3)

CAB013511 HPA016740 HPA020026

Interaction Protein

ENSG00000159840

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications17

PMID	Title	Abstract
39207047	The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available
40465195	Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome.	No abstract available
40831280	Syntenin Controls Extracellular Vesicle-Induced Tumour Migration by Regulating the Expression of Adhesion Proteins on Small Extracellular Vesicles.	No abstract available
40840701	Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma.	No abstract available
40985879	TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins.	No abstract available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No abstract available

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