Protein detail
PDLI5
PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)
Entry name PDLI5 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 17 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein)
Protein Class (3)
Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
EnhLIM
Gene Description
PDZ and LIM domain 5
Chromosome
4
Position
94451857-94668227
Supporting publications (n)
17
EVMP confidence score
0.60
Fluorescence & Localization
Cell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (10)
Molecular Function (7)
Biological Process (3)
Reactome (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence22
Enzyme-Mediated Modification (7)
7 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PDLIM5 | MAPK6 | Q16659 | S | 111 | phosphorylation | PhosphoNetworks | |
| PDLIM5 | MAPK6 | Q16659 | S | 137 | phosphorylation | PhosphoNetworks | |
| PDLIM5 | MAPK6 | Q16659 | S | 313 | phosphorylation | PhosphoNetworks | |
| PDLIM5 | MAPK6 | Q16659 | S | 360 | phosphorylation | PhosphoNetworks | |
| PDLIM5 | MAPK6 | Q16659 | T | 417 | phosphorylation | PhosphoNetworks | |
| PDLIM5 | PDPK1 | O15530 | S | 137 | phosphorylation | PhosphoNetworks | |
| PDLIM5 | PDPK1 | O15530 | S | 319 | phosphorylation | PhosphoNetworks |
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Protein Complex Composition (9)
9 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ACADSBALADCZIBDUS3LPDLIM5RASA1SARS1 | P13716P20936P45954P49591Q96G46Q96HC4Q9NWV4 | 0:0:0:0:0:0:0 | hu.MAP | |||
| FKBP1APDLIM5SUMO3TAGLN2TAGLN3 | P37802P55854P62942Q96HC4Q9UI15 | 0:0:0:0:0 | hu.MAP2 | |||
| MKNK1PDLIM5TTC3 | P53804Q96HC4Q9BUB5 | 0:0:0 | hu.MAP | |||
| DNAJB12MKNK1PDLIM5TTC3 | P53804Q96HC4Q9BUB5Q9NXW2 | 0:0:0:0 | hu.MAP | |||
| CNN3PDLIM5RWDD2B | P57060Q15417Q96HC4 | 0:0:0 | hu.MAP2 | |||
| PDLIM5RWDD2B | P57060Q96HC4 | 0:0 | hu.MAP2 | |||
| CNN3PDLIM5 | Q15417Q96HC4 | 0:0 | hu.MAP2 | |||
| PDLIM5 | Q96HC4 | 5 | PDB | PDB:2uzc | ||
| MKNK1PDLIM5 | Q96HC4Q9BUB5 | 0:0 | hu.MAP |
Sequence, Structure & Domains
Sequences
Length
596
Mass
63,945
Sequence
MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q96HC4-1; Sequence=Displayed; Name=2; IsoId=Q96HC4-2; Sequence=VSP_039075, VSP_039076, VSP_039077, VSP_039078; Name=3; IsoId=Q96HC4-3; Sequence=VSP_039206, VSP_039207, VSP_039077, VSP_039078; Name=4; IsoId=Q96HC4-4; Sequence=VSP_039075; Name=5; IsoId=Q96HC4-5; Sequence=VSP_045098, VSP_045099; Name=6; IsoId=Q96HC4-6; Sequence=VSP_039075, VSP_039076, VSP_053796; Name=7; IsoId=Q96HC4-7; Sequence=VSP_039075, VSP_039076, VSP_053797
Alternative Sequence
33..136; LKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVS -> AGVQWRNLGSPQPPSPEFKRFSCLSLPSSWDYRHVPPRLANFVFLVETKFPYVGQAGLELPTSGDLPTSASQSAKITGVSHRAWPTLFYTLLFFATIYPEIILY (in isoform 5); 98..206; Missing (in isoform 2, isoform 4, isoform 6 and isoform 7); 98..117; GEPKEVVKPVPITSPAVSKV -> KTQVTNNPGTVKIPPKRPPR (in isoform 3); 118..240; Missing (in isoform 3); 137..596; Missing (in isoform 5); 237; G -> GKIPPKR (in isoform 2, isoform 6 and isoform 7); 307..337; NNSQEPSPQLASSVASTRSMPESLDSPTSGR -> KEKIPLHVFSPKYTKLRDWHHEVSARALNVQ (in isoform 2 and isoform 3); 307; N -> KFDSALEDLPKSGPHPPATPQVLTIGSQVATLSKVATTYSSLSSSTGNVEDSFEGFRNFSTFSSPARYSAAVLSSAAATVSAVIATKTRLYTPERYHSLLDALCISPVSKPLAFSYLQSSRKSTGSIHVKKTS (in isoform 6); 338..596; Missing (in isoform 2 and isoform 3); 587..596; Missing (in isoform 7)
3D Structural Models
Turn
413..415; 441..443
Helix
22..24; 38..41; 63..71; 468..474
Beta Strand
3..12; 16..21; 26..33; 49..53; 75..82; 409..411; 419..423; 431..434; 437..439; 447..449; 454..456; 458..463
3D Structure
NMR spectroscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
134..143; Polar residues; 144..165; Low complexity; 205..219; Polar residues; 226..237; Polar residues; 258..273; Basic and acidic residues; 293..304; Basic and acidic residues; 305..335; Polar residues; 361..381; Polar residues
Domain (FT)
2..85; PDZ; 418..477; LIM zinc-binding 1; 477..536; LIM zinc-binding 2; 536..596; LIM zinc-binding 3
Region
121..165; Disordered; 196..240; Disordered; 255..340; Disordered; 354..381; Disordered
Clinical Relevance
Supporting Publications17
| PMID | Title | Related sentences |
|---|---|---|
| 39207047 | The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |
| 40465195 | Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome. | No related sentences available |
| 40831280 | Syntenin Controls Extracellular Vesicle-Induced Tumour Migration by Regulating the Expression of Adhesion Proteins on Small Extracellular Vesicles. | No related sentences available |
| 40840701 | Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma. | No related sentences available |
| 40985879 | TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins. | No related sentences available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No related sentences available |
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