Protein detail

ACY3

N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (EC 3.5.1.114) (Acylase III) (Aminoacylase-3) (ACY-3) (Aspartoacylase-2) (Hepatitis C virus core-binding protein 1) (HCBP1) (HCV core-binding protein 1)

Protein symbol
ACY3
UniProt ID
EVMP score
0.38
Frequency
Transmembrane count
Protein classification
EnzymesMetabolic proteinsPredicted intracellular proteins
Basic Information
Protein Names
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (EC 3.5.1.114) (Acylase III) (Aminoacylase-3) (ACY-3) (Aspartoacylase-2) (Hepatitis C virus core-binding protein 1) (HCBP1) (HCV core-binding protein 1)
Protein Class
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Hydrolases
Entrez Gene Symbol
Gene Synonym
ACY-3HCBP1MGC9740
Gene Description
Aminoacylase 3
Chromosome
11
Position
67642555-67650730
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificMast cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

9 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
apical_cell_membraneplasma_membraneUniProt_locationNoNoNoNoNo
apical_cell_membraneplasma_membraneRamilowski_locationNoNoNoNoNo
plasma_membraneplasma_membraneRamilowski_locationNoNoNoNoNo
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion ChromatographyMass spectrometry1034186243399406413481790628986585278941043064661638321535400890673208974333709510
Sequence, Structure & Domains

Sequences

Length
319
Mass
35,241
Sequence
MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSGCRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKNGLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEKFTFTVPAMPALTPAPSPAS

3D Structural Models

Domain & Motif Annotations

Region
1..210; Hydrolytic domain; 211..318; Shielding domain
Protein Families
  • AspA/AstE family
  • Aspartoacylase subfamily
Sequence Similarities
Belongs to the AspA/AstE family. Aspartoacylase subfamily.
Clinical Relevance