Protein detail

PP16A

Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3)

Entry name PP16A	UniProt ID Q96I34	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000160972

Entrez Gene Symbol

PPP1R16A

Gene Synonym (2)

MGC14333MYPT3

Gene Description

Protein phosphatase 1 regulatory subunit 16A

Chromosome

Position

144477969-144502121

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

Mediation Categories

Metabolism mediation

Relations & Evidence9

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
PGBD5 PPP1R16A PXN RABGGTB	P49023 P53611 Q8N414 Q96I34	0:0:0:0	hu.MAP
PGBD5 PPP1R16A RABGGTA RABGGTB	P53611 Q8N414 Q92696 Q96I34	0:0:0:0	hu.MAP
PGBD5 PPP1R16A RABGGTB	P53611 Q8N414 Q96I34	0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	34202855

Sequence, Structure & Domains7

Sequences

Length

528

Mass

57,811

Sequence

MAEHLELLAEMPMVGRMSTQERLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPVRHLYSKRLDRSVSYQLSPLDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPEGPESPETAEPGLPGDTVTPQPDCGFRAGGDPPLLKLTAPAVEAPVERRPCCLLM

Domain & Motif Annotations

Compositional Bias

40..58; Basic and acidic residues

Repeat

70..99; ANK 1; 103..132; ANK 2; 136..165; ANK 3; 231..260; ANK 4; 264..293; ANK 5

Coiled Coil

18..45

Region

19..59; Disordered; 330..351; Disordered; 367..421; Disordered; 462..505; Disordered

Clinical Relevance4

Antibody

HPA023755

Interaction Protein (3)

ENSG00000179950ENSG00000186298ENSG00000213639

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications3

PMID	Title	Abstract
32560723	T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available