Protein detail

PP16A

Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3)

Entry name
PP16A
UniProt ID
Q96I34
EVMP confidence score
0.40
Supporting publications (n)
3
Transmembrane count
Protein classification
Predicted intracellular proteins
Basic Information
Protein Names
Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000160972
Entrez Gene Symbol
PPP1R16A
Gene Synonym (2)
MGC14333MYPT3
Gene Description
Protein phosphatase 1 regulatory subunit 16A
Chromosome
8
Position
144477969-144502121
Supporting publications (n)
3
EVMP confidence score
0.40
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Mediation Categories
Metabolism mediation
Relations & Evidence9

Ligand-Receptor Signaling (5)

5 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularOmniPath
plasma_membraneplasma_membraneUniProt_location
plasma_membraneplasma_membraneOmniPath

Protein Complex Composition (3)

3 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
PGBD5PPP1R16APXNRABGGTBP49023P53611Q8N414Q96I340:0:0:0hu.MAP
PGBD5PPP1R16ARABGGTARABGGTBP53611Q8N414Q92696Q96I340:0:0:0hu.MAP
PGBD5PPP1R16ARABGGTBP53611Q8N414Q96I340:0:0hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry134202855
Sequence, Structure & Domains

Sequences

Length
528
Mass
57,811
Sequence
MAEHLELLAEMPMVGRMSTQERLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDLYRKQHAQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPVRHLYSKRLDRSVSYQLSPLDSTTPHTLVHDKAHHTLADLKRQRAAAKLQRPPPEGPESPETAEPGLPGDTVTPQPDCGFRAGGDPPLLKLTAPAVEAPVERRPCCLLM

Domain & Motif Annotations

Compositional Bias
40..58; Basic and acidic residues
Repeat
70..99; ANK 1; 103..132; ANK 2; 136..165; ANK 3; 231..260; ANK 4; 264..293; ANK 5
Coiled Coil
18..45
Region
19..59; Disordered; 330..351; Disordered; 367..421; Disordered; 462..505; Disordered
Clinical Relevance
Antibody
HPA023755
Interaction Protein (3)
ENSG00000179950ENSG00000186298ENSG00000213639
Interaction Count
3
Interaction Dataset
intact_biogrid
Supporting Publications3
PMIDTitleRelated sentences
32560723T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.No related sentences available
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No related sentences available
38207106Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.No related sentences available