Protein detail

ZBED3

Zinc finger BED domain-containing protein 3 (Axin-interacting protein)

Entry name ZBED3	UniProt ID Q96IU2	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteinsPredicted secreted proteinsTranscription factors

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Zinc finger BED domain-containing protein 3 (Axin-interacting protein)

Protein Class (3)

Predicted intracellular proteinsPredicted secreted proteinsTranscription factors

Protein Function (3)

Predicted secreted proteins
Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Ensembl

ENSG00000132846

Entrez Gene Symbol

ZBED3

Gene Synonym

MGC15435

Gene Description

Zinc finger BED-type containing 3

Chromosome

Position

77072072-77087285

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecificintestineCell SpecificColonocytes

Function & Pathway5

Protein Function (3)

Predicted secreted proteins
Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Cellular Component (5)

Molecular Function (3)

Biological Process (3)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence10

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	Yes	No	No
ecm	ecm	OmniPath	Yes	No	Yes	No	No
intracellular	intracellular	ComPPI	No	No	Yes	No	No
intracellular	intracellular	GO_Intercell	No	No	Yes	No	No
intracellular	intracellular	UniProt_location	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	2	41068253 33592500

Sequence, Structure & Domains6

Sequences

Length

234

Mass

25,132

Sequence

MRSGEPACTMDQARGLDDAAARGGQCPGLGPAPTPTPPGRLGAPYSEAWGYFHLAPGRPGHPSGHWATCRLCGEQVGRGPGFHAGTSALWRHLRSAHRRELESSGAGSSPPAAPCPPPPGPAAAPEGDWARLLEQMGALAVRGSRRERELERRELAVEQGERALERRRRALQEEERAAAQARRELQAEREALQARLRDVSRREGALGWAPAAPPPLKDDPEGDRDGCVITKVLL

Domain & Motif Annotations

Compositional Bias

111..122; Pro residues; 216..225; Basic and acidic residues

Zinc Finger

43..104; BED-type

Region

19..42; Disordered; 94..126; Disordered; 202..225; Disordered

Clinical Relevance1

Antibody

HPA055995

Supporting Publications1

PMID	Title	Abstract
35988891	YES1 Is a Druggable Oncogenic Target in SCLC.	YES1 levels were evaluated in mouse and patient plasma-derived exosomes.