Protein detail
MRP8
ATP-binding cassette sub-family C member 11 (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 8)
Protein symbol MRP8 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 12 | Protein classification |
Basic Information
Protein Names
ATP-binding cassette sub-family C member 11 (EC 7.6.2.2) (EC 7.6.2.3) (Multidrug resistance-associated protein 8)
Protein Function
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Predicted intracellular proteins
Transmembrane
164..184; Helical; Name=1; 195..215; Helical; Name=2; 271..291; Helical; Name=3; 297..317; Helical; Name=4; 384..404; Helical; Name=5; 418..438; Helical; Name=6; 807..827; Helical; Name=7; 864..884; Helical; Name=8; 931..951; Helical; Name=9; 952..972; Helical; Name=10; 1050..1070; Helical; Name=11; 1075..1095; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificHofbauer cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0005524 ATP binding
- GO:0008514 organic anion transmembrane transporter activity
- GO:0008559 ABC-type xenobiotic transporter activity
- GO:0015216 purine nucleotide transmembrane transporter activity
- GO:0015431 ABC-type glutathione S-conjugate transporter activity
- GO:0015432 ABC-type bile acid transporter activity
- GO:0016887 ATP hydrolysis activity
- GO:0042626 ATPase-coupled transmembrane transporter activity
- GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
1,382
Mass
154,301
Sequence
MTRKRTYWVPNSSGGLVNRGIDIGDDMVSGLIYKTYTLQDGPWSQQERNPEAPGRAAVPPWGKYDAALRTMIPFRPKPRFPAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRRGIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITSGEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALATSLEESLNGNAVPEHQLTQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAALMATATSSLR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96J66-1; Sequence=Displayed; Name=2; Synonyms=Isoform A; IsoId=Q96J66-2; Sequence=VSP_017351
Alternative Sequence
1261..1298; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
504..514; Basic and acidic residues
Domain (FT)
164..443; ABC transmembrane type-1 1; 508..732; ABC transporter 1; 808..1071; ABC transmembrane type-1 2; 1141..1375; ABC transporter 2
Region
504..523; Disordered
Protein Families
- ABC transporter superfamily
- ABCC family
- Conjugate transporter (TC 3.A.1.208) subfamily
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.