Protein detail

COG3

Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94)

Entry name COG3	UniProt ID Q96JB2	EVMP confidence score 0.50
Supporting publications (n) 5	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94)

Protein Class (2)

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000136152

Entrez Gene Symbol

COG3

Gene Synonym

SEC34

Gene Description

Component of oligomeric golgi complex 3

Chromosome

Position

45464898-45536701

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (8)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Reactome (10)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence13

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (8)

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
COG complex	COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8	P83436 Q14746 Q8WTW3 Q96JB2 Q96MW5 Q9H9E3 Q9UP83 Q9Y2V7	1:1:1:1:1:1:1:1	Havugimana2012CORUMComplexPortalCompleathu.MAP2hu.MAP	Havugimana2012:C_559CORUM:162intact:EBI-26354046Compleat:HC494	11980916 15047703 16020545 27066481 14755292 31381138
COG1-COG8-COG2-COG3-COG4 subcomplex	COG1 COG2 COG3 COG4 COG8	Q14746 Q8WTW3 Q96JB2 Q96MW5 Q9H9E3	1:1:1:1:1	CompleatCORUM	Compleat:HC900CORUM:3551	16020545
COG2-COG3-COG4 subcomplex	COG2 COG3 COG4	Q14746 Q96JB2 Q9H9E3	1:1:1	CompleatCORUM	CORUM:3544Compleat:HC92	16020545
Golgi transport complex	COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8 GOLGA3 SCFD1	P83436 Q08378 Q14746 Q8WTW3 Q8WVM8 Q96JB2 Q96MW5 Q9H9E3 Q9UP83 Q9Y2V7	1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC975	9792665 7962052 8315394 11980916 11703943 15047703 11292827
Golgi transport complex	COG3 COG4 COG6 COG8	Q96JB2 Q96MW5 Q9H9E3 Q9Y2V7	1:1:1:1	Compleat	Compleat:HC28	11703943
	BET1L COG3 COG4 COG6 GOSR1 GOSR2 NAPA NSF SCFD1 SEC22B STX12 STX5 UBC VTI1B YKT6	O14653 O15498 O75396 O95249 P0CG48 P46459 P54920 Q13190 Q86Y82 Q8WVM8 Q96JB2 Q9H9E3 Q9NYM9 Q9UEU0 Q9Y2V7	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7766
	COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8 MTOR	P42345 P83436 Q14746 Q8WTW3 Q96JB2 Q96MW5 Q9H9E3 Q9UP83 Q9Y2V7	0:0:0:0:0:0:0:0:0	hu.MAP
	ATP7A COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8	P83436 Q04656 Q14746 Q8WTW3 Q96JB2 Q96MW5 Q9H9E3 Q9UP83 Q9Y2V7	0:0:0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	2	38113368 37322475

Sequence, Structure & Domains9

Sequences

Length

828

Mass

94,096

Sequence

MAEAALLLLPEAAAERDAREKLALWDRRPDTTAPLTDRQTDSVLELKAAAENLPVPAELPIEDLCSLTSQSLPIELTSVVPESTEDILLKGFTSLGMEEERIETAQQFFSWFAKLQTQMDQDEGTKYRQMRDYLSGFQEQCDAILNDVNSALQHLESLQKQYLFVSNKTGTLHEACEQLLKEQSELVDLAENIQQKLSYFNELETINTKLNSPTLSVNSDGFIPMLAKLDDCITYISSHPNFKDYPIYLLKFKQCLSKALHLMKTYTVNTLQTLTSQLLKRDPSSVPNADNAFTLFYVKFRAAAPKVRTLIEQIELRSEKIPEYQQLLNDIHQCYLDQRELLLGPSIACTVAELTSQNNRDHCALVRSGCAFMVHVCQDEHQLYNEFFTKPTSKLDELLEKLCVSLYDVFRPLIIHVIHLETLSELCGILKNEVLEDHVQNNAEQLGAFAAGVKQMLEDVQERLVYRTHIYIQTDITGYKPAPGDLAYPDKLVMMEQIAQSLKDEQKKVPSEASFSDVHLEEGESNSLTKSGSTESLNPRPQTTISPADLHGMWYPTVRRTLVCLSKLYRCIDRAVFQGLSQEALSACIQSLLGASESISKNKTQIDGQLFLIKHLLILREQIAPFHTEFTIKEISLDLKKTRDAAFKILNPMTVPRFFRLNSNNALIEFLLEGTPEIREHYLDSKKDVDRHLKSACEQFIQQQTKLFVEQLEEFMTKVSALKTMASQGGPKYTLSQQPWAQPAKVNDLAATAYKTIKTKLPVTLRSMSLYLSNKDTEFILFKPVRNNIQQVFQKFHALLKEEFSPEDIQIIACPSMEQLSLLLLVSK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96JB2-1; Sequence=Displayed; Name=2; IsoId=Q96JB2-2; Sequence=VSP_013652, VSP_013653

Alternative Sequence

443..444; AE -> GK (in isoform 2); 445..828; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

525..543; Polar residues

Region

504..543; Disordered

Protein Families

COG3 family

Sequence Similarities

Belongs to the COG3 family.

Clinical Relevance5

Disease Involvement

Congenital disorder of glycosylation

Antibody (2)

HPA040353 HPA054470

Interaction Protein (4)

ENSG00000135775ENSG00000166685ENSG00000168434ENSG00000213380

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications5

PMID	Title	Abstract
16708399	Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells.	We found that HS-Exo, compared with control exosomes derived from the same cells (Exo), contain more HSP60 and HSP90 and increased amounts of molecules involved in immunogenicity including MHC class I, MHC class II, CD40, CD86, RANTES and IL-1beta.
17868797	B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines.	Exosomes from antigen-presenting cells carry immunorelevant molecules like MHC class I and II and costimulatory molecules and thus are suggested to have a role in immune modulation. RESULTS: The exosomes had a phenotype typical of B cell-derived exosomes with expression of MHC, costimulatory molecules like CD86, tetraspanin proteins such as CD81, and CD19.
21044087	Exosomal-like vesicles with immune-modulatory features are present in human plasma and can induce CD4+ T-cell apoptosis in vitro.	Antibodies against exosomes FasL can block the activity of exosomes on CD4+ T-cell apoptosis. Moreover, three different concentrations of CD4+ T cells were inhibited by plasma exosomes and the suppressive function was not dependent on interleukin-2. RESULTS: Vesicles purified from human plasma displayed shapes and sizes similar to those of previously described exosomes and contained exosomes marker proteins CD63 and CD81.
37960298	Application of Milk Exosomes for Musculoskeletal Health: Talking Points in Recent Outcomes.	Discovered through electron microscopy as floating vesicles, the existence of exosomes in human milk was confirmed owing to a density between 1.10 and 1.18 g/mL in a sucrose gradient corresponding to the known density of exosomes and detection of MHC classes I and II, CD63, CD81, and CD86 on the vesicles.
37993261	Hypoxia-regulated exosomes mediate M2 macrophage polarization and promote metastasis in chondrosarcoma.	These hypoxia-induced exosomes promoted macrophage polarization towards the M2 phenotype, characterized by the expression of CD163 and CD206, but not the M1 phenotype, characterized by CD86 expression.