Protein detail

SC16B

Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B)

Entry name SC16B	UniProt ID Q96JE7	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000120341

Entrez Gene Symbol

SEC16B

Gene Synonym (4)

LZTR2PGPR-p117RGPRSec16S

Gene Description

SEC16 homolog B, endoplasmic reticulum export factor

Chromosome

Position

177923956-177984303

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (6)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Reactome (7)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence7

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TFG	Q92734	SC16B	Q96JE7	Yes	Yes	No	SIGNOR	SIGNOR:21478858

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_SC_Cluster81	SEC16A SEC16B SEC23A SEC23B SEC24A SEC24B SEC24C SEC24D	O15027 O94855 O95486 O95487 P53992 Q15436 Q15437 Q96JE7	1:1:1:1:1:1:1:1	Compleat	Compleat:HC1835

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	5	41068253 33592500 38014595 40730843 41307968

Sequence, Structure & Domains9

Sequences

Length

1,060

Mass

116,604

Sequence

MELWAPQRLPQTRGKATAPSKDPDRGFRRDGHHRPVPHSWHNGERFHQWQDNRGSPQPQQEPRADHQQQPHYASRPGDWHQPVSGVDYYEGGYRNQLYSRPGYENSYQSYQSPTMREEYAYGSYYYHGHPQWLQEERVPRQRSPYIWHEDYREQKYLDEHHYENQHSPFGTNSETHFQSNSRNPCKDSPASNSGQEWPGELFPGSLLAEAQKNKPSLASESNLLQQRESGLSSSSYELSQYIRDAPERDDPPASAAWSPVQADVSSAGPKAPMKFYIPHVPVSFGPGGQLVHVGPSSPTDGQAALVELHSMEVILNDSEEQEEMRSFSGPLIREDVHKVDIMTFCQQKAAQSCKSETLGSRDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDEDWPVLSSGTPNLLTGEIPPSVETPAQIVEKFTRLLYYGRKKEALEWAMKNHLWGHALFLSSKMDPQTYSWVMSGFTSTLALNDPLQTLFQLMSGRIPQAATCCGEKQWGDWRPHLAVILSNQAGDPELYQRAIVAIGDTLAGKGLVEAAHFCYLMAHVPFGHYTVKTDHLVLLGSSHSQEFLKFATTEAIQRTEIFEYCQMLGRPKSFIPSFQVYKLLYASRLADYGLVSQALHYCEAIGAAVLSQGESSHPVLLVELIKLAEKLKLSDPLVLERRSGDRDLEPDWLAQLRRQLEQKVAGDIGDPHPTRSDISGAGGTTTENTFYQDFSGCQGYSEAPGYRSALWLTPEQTCLLQPSPQQPFPLQPGSYPAGGGAGQTGTPRPFYSVPETHLPGTGSSVAVTEATGGTVWEEMLQTHLGPGENTVSQETSQPPDGQEVISKPQTPLAARPRSISESSASSAKEDEKESSDEADKNSPRNTAQRGKLGDGKEHTKSSGFGWFSWFRSKPTKNASPAGDEDSSDSPDSEETPRASSPHQAGLGLSLTPSPESPPLPDVSAFSRGRGGGEGRGSASSGGAAAGAGVGGLSGPESVSFELCSNPGVLLPPPALKGAVPLYNPSQVPQLPTATSLNRPNRLAQRRYPTQPC

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96JE7-1; Sequence=Displayed; Name=2; IsoId=Q96JE7-2; Sequence=VSP_034373, VSP_034374; Name=3; IsoId=Q96JE7-3; Sequence=VSP_034371, VSP_034372, VSP_034375, VSP_034376

Alternative Sequence

1..435; Missing (in isoform 3); 436..515; ETPAQIVEKFTRLLYYGRKKEALEWAMKNHLWGHALFLSSKMDPQTYSWVMSGFTSTLALNDPLQTLFQLMSGRIPQAAT -> MRGFVHFHHAAYSFLPPGGILLPLHRPSWATWLDFLILKVAVGTRLHRVPVKIKRMCVNGLCRARKHRHL (in isoform 3); 592..624; SQEFLKFATTEAIQRTEIFEYCQMLGRPKSFIP -> RYATWEKGNSKDIFQGTVLALVGFYGSSFHFLM (in isoform 2); 625..1060; Missing (in isoform 2); 942..986; ETPRASSPHQAGLGLSLTPSPESPPLPDVSAFSRGRGGGEGRGSA -> VGVKAEDPHPAGGQLRALGLEACLDQRVFPLSSAPTLVFFFLHLP (in isoform 3); 987..1060; Missing (in isoform 3)

Domain & Motif Annotations

Compositional Bias

41..50; Basic and acidic residues; 51..60; Polar residues; 165..195; Polar residues; 213..222; Polar residues; 223..236; Low complexity; 837..847; Polar residues; 875..890; Basic and acidic residues; 899..908; Basic and acidic residues; 909..918; Low complexity; 930..941; Acidic residues; 991..1001; Gly residues; 1031..1046; Polar residues

Region

1..86; Disordered; 34..224; Required for endoplasmic reticulum localization; 163..236; Disordered; 245..264; Disordered; 271..713; Central conserved domain (CCD); required for localization to endoplasmic reticulum exit sites; 711..733; Disordered; 770..796; Disordered; 834..1060; Disordered

Protein Families

SEC16 family

Sequence Similarities

Belongs to the SEC16 family.

Clinical Relevance4

Antibody (2)

HPA054292 HPA072913

Interaction Protein

ENSG00000157020

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
30550287	Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.	No abstract available