Protein detail
KCNS1
Delayed-rectifier potassium channel regulatory subunit KCNS1 (Delayed-rectifier K(+) channel alpha subunit 1) (Delayed-rectifier potassium channel subunit Kv9.1) (hKv9.1) (Potassium voltage-gated channel modifier subfamily S member 1)
Entry name KCNS1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 6 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Delayed-rectifier potassium channel regulatory subunit KCNS1 (Delayed-rectifier K(+) channel alpha subunit 1) (Delayed-rectifier potassium channel subunit Kv9.1) (hKv9.1) (Potassium voltage-gated channel modifier subfamily S member 1)
Protein Function
- Transporters:Transporter channels and pores
- Voltage-gated ion channels:Voltage-Gated Potassium Channels
Transmembrane
218..239; Helical; Name=Segment S1; 271..293; Helical; Name=Segment S2; 305..322; Helical; Name=Segment S3; 338..358; Helical; Voltage-sensor; Name=Segment S4; 374..395; Helical; Name=Segment S5; 436..464; Helical; Name=Segment S6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Transporters:Transporter channels and pores
- Voltage-gated ion channels:Voltage-Gated Potassium Channels
Cellular Component
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
28 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| potassium | ion_channel | Almen2009 | No | Yes | No | No | No |
| voltage_gated | ion_channel | Almen2009 | No | Yes | No | No | No |
| voltage_gated | ion_channel | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
526
Mass
58,372
Sequence
MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQSADLESQAPSEPPHPQMY
3D Structural Models
Domain & Motif Annotations
Compositional Bias
505..517; Polar residues
Motif
421..426; Selectivity filter
Domain (CC)
The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.
Region
493..526; Disordered
Protein Families
- Potassium channel family
- S (TC 1.A.1.2) subfamily
- Kv9.1/KCNS1 sub-subfamily
Sequence Similarities
Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.