Protein detail

PGRP4

Peptidoglycan recognition protein 4 (Peptidoglycan recognition protein I-beta) (PGLYRPIbeta) (PGRP-I-beta) (Peptidoglycan recognition protein intermediate beta)

Entry name PGRP4	UniProt ID Q96LB8	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Peptidoglycan recognition protein 4 (Peptidoglycan recognition protein I-beta) (PGLYRPIbeta) (PGRP-I-beta) (Peptidoglycan recognition protein intermediate beta)

Protein Function

Predicted secreted proteins

Ensembl

ENSG00000163218

Entrez Gene Symbol

PGLYRP4

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificEsophageal apical cells

Function & Pathway6

Protein Function

Predicted secreted proteins

Cellular Component (3)

Molecular Function (5)

Biological Process (3)

Reactome (2)

Mediation Categories

Immune mediation

Relations & Evidence11

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	Yes	No	No
ecm	ecm	OmniPath	Yes	No	Yes	No	No
extracellular	extracellular	OmniPath	No	No	Yes	No	No
peptidoglycan	secreted_receptor	HGNC	Yes	No	Yes	No	No
secreted_receptor	secreted_receptor	OmniPath	Yes	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PGLYRP4	Q96LB8	2	PDB	PDB:2eavPDB:2eax

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Antibody arrayMass spectrometryWestern blotting	4	39873726 38731868 24657793 37922300

Sequence, Structure & Domains13

Sequences

Length

373

Mass

40,620

Sequence

MLPWLLVFSALGIQAWGDSSWNKTQAKQVSEGLQYLFENISQLTEKGLPTDVSTTVSRKAWGAEAVGCSIQLTTPVNVLVIHHVPGLECHDQTVCSQRLRELQAHHVHNNSGCDVAYNFLVGDDGRVYEGVGWNIQGVHTQGYNNISLGFAFFGTKKGHSPSPAALSAMENLITYAVQKGHLSSSYVQPLLGKGENCLAPRQKTSLKKACPGVVPRSVWGARETHCPRMTLPAKYGIIIHTAGRTCNISDECRLLVRDIQSFYIDRLKSCDIGYNFLVGQDGAIYEGVGWNVQGSSTPGYDDIALGITFMGTFTGIPPNAAALEAAQDLIQCAMVKGYLTPNYLLVGHSDVARTLSPGQALYNIISTWPHFKH

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96LB8-1; Sequence=Displayed; Name=2; IsoId=Q96LB8-2; Sequence=VSP_024388

Alternative Sequence

47..50; Missing (in isoform 2)

3D Structural Models

Turn

298..300

Helix

216..219; 249..265; 301..303; 320..335; 348..351; 359..365

Beta Strand

212..214; 231..240; 275..278; 284..288; 290..292; 304..311; 314..316; 338..347; 352..354

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)

74..212; N-acetylmuramoyl-L-alanine amidase 1; 235..358; N-acetylmuramoyl-L-alanine amidase 2

Region

293..302; Interaction with murein; 353..354; Interaction with murein

Protein Families

N-acetylmuramoyl-L-alanine amidase 2 family

Sequence Similarities

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Clinical Relevance1

Drugs

NULL

Supporting Publications1

PMID	Title	Abstract
40689422	Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles.	No abstract available