Protein detail

SGCZ

Zeta-sarcoglycan (Zeta-SG) (ZSG1)

Entry name SGCZ	UniProt ID Q96LD1	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Zeta-sarcoglycan (Zeta-SG) (ZSG1)

Protein Class

Predicted membrane proteins

Transmembrane

38..58; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000185053

Entrez Gene Symbol

SGCZ

Gene Synonym

ZSG1

Gene Description

Sarcoglycan zeta

Chromosome

Position

14084845-15238431

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Tissue SpecifictestisCell SpecificCardiomyocytes

Function & Pathway5

Cellular Component (4)

Biological Process (3)

KEGG (5)

Reactome (3)

Mediation Categories

Other mediation

Relations & Evidence28

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No

Page 2 of 3Previous Next

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	N4BP1 NR2C2AP RANGRF SGCZ SP3	O75113 Q02447 Q86WQ0 Q96LD1 Q9HD47	0:0:0:0:0	hu.MAP2
	RANGRF SGCZ SP3	Q02447 Q96LD1 Q9HD47	0:0:0	hu.MAPhu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blotting	4	39873726 38731868 41201090 36982312

Sequence, Structure & Domains7

Sequences

Length

299

Mass

32,949

Sequence

MTREQYILATQQNNLPRTENAQLYPVGIYGWRKRCLYFFVLLLLVTMIVNLAMTIWILKVMNFTVDGMGNLRVTKKGIRLEGISEFLLPLYVKEIHSRKDSPLVLQSDRNVTVNARNHMGQLTGQLTIGADAVEAQCKRFEVRASEDGRVLFSADEDEITIGAEKLKVTGTEGAVFGHSVETPHIRAEPSQDLRLESPTRSLIMEAPRGVQVSAAAGDFKATCRKELHLQSTEGEIFLNAETIKLGNLPTGSFSSSSPSSSSSRQTVYELCVCPNGKLYLSPAGVGSTCQSSSNICLWS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96LD1-1; Sequence=Displayed; Name=2; IsoId=Q96LD1-2; Sequence=VSP_037410

Alternative Sequence

1; M -> MDRSTNLDIEELKM (in isoform 2)

Domain & Motif Annotations

Protein Families

Sarcoglycan beta/delta/gamma/zeta family

Sequence Similarities

Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Clinical Relevance1

Antibody

HPA017585

Supporting Publications1

PMID	Title	Abstract
38795909	Proteomic profile of tissue-derived extracellular vesicles from benign odontogenic lesions.	No abstract available