Protein detail
HYLS1
Centriolar and ciliogenesis-associated protein HYLS1 (Hydrolethalus syndrome protein 1)
Entry name HYLS1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Centriolar and ciliogenesis-associated protein HYLS1 (Hydrolethalus syndrome protein 1)
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ32915
Gene Description
HYLS1 centriolar and ciliogenesis associated
Chromosome
11
Position
125883614-125900646
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificlungCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted - unknown locationSecretome FunctionReceptor
Function & Pathway
Protein Function (3)
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Cellular Component (8)
Molecular Function
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence5
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationMicrofluidics-Based Methods | Mass spectrometry | 1 | 41167904 |
Sequence, Structure & Domains
Sequences
Length
299
Mass
34,359
Sequence
MEELLPDGQIWANMDPEERMLAAATAFTHICAGQGEGDVRREAQSIQYDPYSKASVAPGKRPALPVQLQYPHVESNVPSETVSEASQRLRKPVMKRKVLRRKPDGEVLVTDESIISESESGTENDQDLWDLRQRLMNVQFQEDKESSFDVSQKFNLPHEYQGISQDQLICSLQREGMGSPAYEQDLIVASRPKSFILPKLDQLSRNRGKTDRVARYFEYKRDWDSIRLPGEDHRKELRWGVREQMLCRAEPQSKPQHIYVPNNYLVPTEKKRSALRWGVRCDLANGVIPRKLPFPLSPS
Domain & Motif Annotations
Protein Families
HYLS1 family
Sequence Similarities
Belongs to the HYLS1 family.
Clinical Relevance
Disease Involvement (2)
CiliopathyDisease variant
Antibody
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 27821849 | Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation. | No related sentences available |
| 38716512 | Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics. | No related sentences available |