Protein detail
ROBO3
Roundabout homolog 3 (Roundabout-like protein 3)
Entry name ROBO3 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Roundabout homolog 3 (Roundabout-like protein 3)
Protein Function (3)
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Transmembrane
892..912; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
3
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue Specificadrenal glandCell SpecificCardiomyocytesSingle-Nuclei Brain Specificoligodendrocyte precursor cell
Function & Pathway6
Protein Function (3)
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Cellular Component (3)
Molecular Function (2)
Reactome (5)
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence49
Enzyme-Mediated Modification (2)
Ligand-Receptor Signaling (41)
41 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
Page 5 of 5Previous
Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ROBO3 | Q96MS0 | COF1 | P23528 | Yes | Yes | No | SIGNOR | SIGNOR:16226035 |
| SLIT2 | O94813 | ROBO3 | Q96MS0 | Yes | Yes | No | SIGNOR | SIGNOR:16226035 |
| KPCA | P17252 | ROBO3 | Q96MS0 | Yes | No | No | iPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:25882844 |
Protein Complex Composition (2)
Sequence, Structure & Domains14
Sequences
Length
1,386
Mass
148,209
Sequence
MLRYLLKTLLQMNLFADSLAGDISNSSELLLGFNSSLAALNHTLLPPGDPSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPDLEPGLEVGAGLAVRLARVLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSEGLSGASSRPPMGLGPAPYSWLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAAPGEGPVYSTIDPAGEELQTFHGGFPQHPSGDLGPWSQYAPPEWSQGDSGAKGGKVKLLGKPVQMPSLNWPEALPPPPPSCELSCLEGPEEELEGSSEPEEWCPPMPERSHLTEPSSSGGCLVTPSRRETPSPTPSYGQQSTATLTPSPPDPPQPPTDMPHLHQMPRRVPLGPSSPLSVSQPMLGIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKALPYRRENSPGDLPPPPLPPPEEEASWALELRAAGSMSSLERERSGERKAVQAVPLAAQRVLHPDEEAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQSRSQSQRPGQKRREEPR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Robo3.1; IsoId=Q96MS0-1; Sequence=Displayed; Name=2; IsoId=Q96MS0-2; Sequence=VSP_010650, VSP_010651
Alternative Sequence
1025..1034; AGEELQTFHG -> LTTPLLILTT (in isoform 2); 1035..1386; Missing (in isoform 2)
3D Structural Models
Turn
596..598
Helix
696..698; 796..799; 815..817
Beta Strand
563..567; 572..575; 588..594; 603..609; 611..616; 624..633; 672..675; 686..694; 701..708; 717..721; 728..731; 738..747; 759..762; 773..779; 782..785; 787..792; 805..811; 819..824; 829..832; 840..849; 852..856; 860..863
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
546..559; Pro residues; 1067..1083; Low complexity; 1099..1112; Acidic residues; 1158..1169; Pro residues; 1178..1191; Low complexity; 1202..1229; Low complexity; 1294..1304; Basic and acidic residues; 1333..1344; Polar residues; 1345..1361; Low complexity
Domain (FT)
64..160; Ig-like C2-type 1; 166..253; Ig-like C2-type 2; 258..342; Ig-like C2-type 3; 347..440; Ig-like C2-type 4; 450..531; Ig-like C2-type 5; 558..652; Fibronectin type-III 1; 671..766; Fibronectin type-III 2; 771..869; Fibronectin type-III 3
Region
541..563; Disordered; 639..662; Disordered; 965..989; Disordered; 1028..1310; Disordered; 1327..1386; Disordered
Protein Families (2)
- Immunoglobulin superfamily
- ROBO family
Sequence Similarities
Belongs to the immunoglobulin superfamily. ROBO family.
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 24505114 | Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform. | These included proteins of known association with cancer exosomes such as MFG-E8, integrins, and MET, and also those less widely reported as exosomally associated, such as ROR1 and ITIH4. |
| 31588238 | Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |