Protein detail

RN145

RING finger protein 145 (EC 2.3.2.27)

Entry name RN145	UniProt ID Q96MT1	EVMP score 0.50
Frequency 1	Transmembrane count 14	Protein classification EnzymesPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

RING finger protein 145 (EC 2.3.2.27)

Protein Class

EnzymesPredicted membrane proteins

Protein Function

ENZYME proteins:Transferases
Enzymes

Transmembrane

53..73; Helical; 77..97; Helical; 123..143; Helical; 146..166; Helical; 168..188; Helical; 205..222; Helical; 225..245; Helical; 275..295; Helical; 316..336; Helical; 340..360; Helical; 384..404; Helical; 410..430; Helical; 460..480; Helical; 482..502; Helical

Transmembrane Count

Ensembl

ENSG00000145860

Entrez Gene Symbol

RNF145

Gene Synonym

FLJ31951

Gene Description

Ring finger protein 145

Chromosome

Position

159157409-159210053

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificplacentaCell SpecificEndometrial glandular cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificplasmacytoid DCSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function

Function & Pathway

Protein Function

ENZYME proteins:Transferases
Enzymes

Cellular Component

Molecular Function

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

Regulatory Interaction Network

136 records.

Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
COMPLEX:P62979_Q96B02	RN145	Q96MT1	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_Q9NR09	RN145	Q96MT1	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62979_Q96LR5	RN145	Q96MT1	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_P49459	RN145	Q96MT1	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:O00762_P0CG48	RN145	Q96MT1	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_Q969T4	RN145	Q96MT1	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_Q5JXB2	RN145	Q96MT1	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62979_Q16763	RN145	Q96MT1	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_Q712K3	RN145	Q96MT1	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_Q7Z7E8	RN145	Q96MT1	Yes	Yes	No	SIGNOR	SIGNOR:34199813

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Protein Complex Composition

7 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
Ub:RING_E3	RNF145 UBB	P0CG47 Q96MT1	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RNF145 UBC	P0CG48 Q96MT1	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RNF145 RPS27A	P62979 Q96MT1	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RNF145 UBA52	P62987 Q96MT1	0:0	SIGNOR	SIGNOR:SIGNOR-C519
	AK1 HDLBP RNF145 SRM UBC	P00568 P0CG48 P19623 Q00341 Q96MT1	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7877
	CMPK1 HDLBP RNF145 SRM UBC	P0CG48 P19623 P30085 Q00341 Q96MT1	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9461
	HDLBP RNF145 SMS SRM UBC	P0CG48 P19623 P52788 Q00341 Q96MT1	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8004

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation；Size Exclusion Chromatography	Flow cytometryMORPH	1	41216884

Sequence, Structure & Domains

Sequences

Length

663

Mass

75,617

Sequence

MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLSNNPLFQYKYLALNMHYVGYILSVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSELEFAYEGPMYLEPLSMNRFTTALIGQLVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPIATKEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSSQLPGLGTEPVLQPHAGAEQNVMFQEGTEPPGQEHTPGTRIQEGSRDNNEYIARRPDNQEGAFDPKEYPHSAKDEAHPVESA

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q96MT1-1; Sequence=Displayed; Name=2; IsoId=Q96MT1-2; Sequence=VSP_037501; Name=3; IsoId=Q96MT1-3; Sequence=VSP_043661; Name=4; IsoId=Q96MT1-4; Sequence=VSP_043662; Name=5; IsoId=Q96MT1-5; Sequence=VSP_044539

Alternative Sequence

1; M -> MMRNHRIASSLCGDQVFSKKKKKKKKNNM (in isoform 2); 1; M -> MAEVVFSKKKKKKKKNNM (in isoform 3); 1; M -> MVFSKKKKKKKKNNM (in isoform 4); 1; M -> MHRDRISPSNSPTWSLQVFSKKKKKKKKNNM (in isoform 5)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

624..663; Basic and acidic residues

Motif

81..84; YLYF motif

Zinc Finger

537..575; RING-type; atypical

Region

607..663; Disordered

Clinical Relevance

Antibody

HPA036562