Protein detail
RN145
RING finger protein 145 (EC 2.3.2.27)
Entry name RN145 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 14 | Protein classification EnzymesPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
RING finger protein 145 (EC 2.3.2.27)
Protein Class (2)
EnzymesPredicted membrane proteins
Protein Function (2)
- ENZYME proteins:Transferases
- Enzymes
Transmembrane
53..73; Helical; 77..97; Helical; 123..143; Helical; 146..166; Helical; 168..188; Helical; 205..222; Helical; 225..245; Helical; 275..295; Helical; 316..336; Helical; 340..360; Helical; 384..404; Helical; 410..430; Helical; 460..480; Helical; 482..502; Helical
Transmembrane Count
14
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ31951
Gene Description
Ring finger protein 145
Chromosome
5
Position
159157409-159210053
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificplacentaCell SpecificEndometrial glandular cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificplasmacytoid DCSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function
Function & Pathway
Protein Function (2)
- ENZYME proteins:Transferases
- Enzymes
Cellular Component (2)
Molecular Function (2)
Mediation Categories
Other mediation
Relations & Evidence153
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| transmembrane | transmembrane_predicted | Phobius |
Regulatory Interaction Network (136)
136 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:P0CG48_Q9Y2X8 | RN145 | Q96MT1 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P0CG47_P63146 | RN145 | Q96MT1 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:A0A1B0GUS4_P0CG47 | RN145 | Q96MT1 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P62979_Q9NR09 | RN145 | Q96MT1 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P0CG48_Q5JXB2 | RN145 | Q96MT1 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P62979_Q5VVX9 | RN145 | Q96MT1 | Yes | Yes | SIGNOR | SIGNOR:34199813 |
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Protein Complex Composition (7)
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Ub:RING_E3 | RNF145UBB | P0CG47Q96MT1 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | RNF145UBC | P0CG48Q96MT1 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | RNF145RPS27A | P62979Q96MT1 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | RNF145UBA52 | P62987Q96MT1 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| AK1HDLBPRNF145SRMUBC | P00568P0CG48P19623Q00341Q96MT1 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7877 | ||
| CMPK1HDLBPRNF145SRMUBC | P0CG48P19623P30085Q00341Q96MT1 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9461 | ||
| HDLBPRNF145SMSSRMUBC | P0CG48P19623P52788Q00341Q96MT1 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8004 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Size Exclusion Chromatography | Flow cytometryMORPH | 1 | 41216884 |
Sequence, Structure & Domains
Sequences
Length
663
Mass
75,617
Sequence
MAAKEKLEAVLNVALRVPSIMLLDVLYRWDVSSFFQQIQRSSLSNNPLFQYKYLALNMHYVGYILSVVLLTLPRQHLVQLYLYFLTALLLYAGHQISRDYVRSELEFAYEGPMYLEPLSMNRFTTALIGQLVVCTLCSCVMKTKQIWLFSAHMLPLLARLCLVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVVEVYGLLALGMSLWNQLVVPVLFMVFWLVLFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFLVALCVVAYGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSLPIATKEQLEKHNDICAICYQDMKSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSSQLPGLGTEPVLQPHAGAEQNVMFQEGTEPPGQEHTPGTRIQEGSRDNNEYIARRPDNQEGAFDPKEYPHSAKDEAHPVESA
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q96MT1-1; Sequence=Displayed; Name=2; IsoId=Q96MT1-2; Sequence=VSP_037501; Name=3; IsoId=Q96MT1-3; Sequence=VSP_043661; Name=4; IsoId=Q96MT1-4; Sequence=VSP_043662; Name=5; IsoId=Q96MT1-5; Sequence=VSP_044539
Alternative Sequence
1; M -> MMRNHRIASSLCGDQVFSKKKKKKKKNNM (in isoform 2); 1; M -> MAEVVFSKKKKKKKKNNM (in isoform 3); 1; M -> MVFSKKKKKKKKNNM (in isoform 4); 1; M -> MHRDRISPSNSPTWSLQVFSKKKKKKKKNNM (in isoform 5)
Domain & Motif Annotations
Compositional Bias
624..663; Basic and acidic residues
Motif
81..84; YLYF motif
Zinc Finger
537..575; RING-type; atypical
Region
607..663; Disordered
Clinical Relevance
Antibody
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No related sentences available |