Protein detail

ZN599

Zinc finger protein 599

Entry name ZN599	UniProt ID Q96NL3	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteinsTranscription factors

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Zinc finger protein 599

Protein Class (2)

Predicted intracellular proteinsTranscription factors

Protein Function (2)

Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Ensembl

ENSG00000153896

Entrez Gene Symbol

ZNF599

Gene Synonym

FLJ30663

Gene Description

Zinc finger protein 599

Chromosome

Position

34758073-34773229

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue Specificlymphoid tissueCell SpecificEarly spermatidsSingle-Nuclei Brain Specificdeep-layer intratelencephalic

Function & Pathway6

Protein Function (2)

Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Cellular Component

GO:0005634 nucleus

Molecular Function (4)

Biological Process (3)

Reactome

R-hsa-73857 rna polymerase ii transcription

Mediation Categories

Other mediation

Relations & Evidence5

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryELISA	2	39873726 40784529

Sequence, Structure & Domains9

Sequences

Length

588

Mass

67,492

Sequence

MAAPALALVSFEDVVVTFTGEEWGHLDLAQRTLYQEVMLETCRLLVSLGHPVPKPELIYLLEHGQELWTVKRGLSQSTCAGEKAKPKITEPTASQLAFSEESSFQELLAQRSSRDSRLGQARDEEKLIKIQEGNLRPGTNPHKEICPEKLSYKHDDLEPDDSLGLRVLQERVTPQDALHECDSQGPGKDPMTDARNNPYTCTECGKGFSKKWALVRHQQIHAGVKPYECNECGKACRYMADVIRHMRLHTGEKPYKCIECGKAFKRRFHLTEHQRIHTGDKPYECKECGKAFTHRSSFIQHNMTHTREKPFLCKECGKAFYYSSSFAQHMRIHTGKKLYECGECGKAFTHRSTFIQHNVTHTGEKPFLCKECGKTFCLNSSFTQHMRIHTGEKPYECGECGKAFTHRSTFIRHKRTHTGEKPFECKECGKAFCDSSSLIQHMRIHTGEKPYECSECGKAFTHHSVFIRHNRTHSGQKPLECKECAKAFYYSSSFTRHMRIHTGEKPYVCRECGKAFTQPANFVRHNRIHTGEKPFECKECEKAFCDNFALTQHMRTHTGEKPFECNECGKTFSHSSSFTHHRKIHTRV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96NL3-1; Sequence=Displayed; Name=2; IsoId=Q96NL3-2; Sequence=VSP_018385, VSP_018386

Alternative Sequence

81..95; GEKAKPKITEPTASQ -> ASFSLLWKSYHPGHG (in isoform 2); 96..588; Missing (in isoform 2)

Domain & Motif Annotations

Zinc Finger

199..221; C2H2-type 1; 227..249; C2H2-type 2; 255..277; C2H2-type 3; 283..305; C2H2-type 4; 311..333; C2H2-type 5; 339..361; C2H2-type 6; 367..389; C2H2-type 7; 395..417; C2H2-type 8; 423..445; C2H2-type 9; 451..473; C2H2-type 10; 479..501; C2H2-type 11; 507..529; C2H2-type 12; 535..557; C2H2-type 13; 563..585; C2H2-type 14

Domain (FT)

9..80; KRAB

Protein Families

Krueppel C2H2-type zinc-finger protein family

Sequence Similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Clinical Relevance1

Antibody

HPA014701

Supporting Publications1

PMID	Title	Abstract
37926697	Analysis of small EV proteomes reveals unique functional protein networks regulated by VAP-A.	No abstract available