Protein detail

CF418

Cilia- and flagella-associated protein 418

Entry name CF418	UniProt ID Q96NL8	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Cilia- and flagella-associated protein 418

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (4)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Eye disease
Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism

Ensembl

ENSG00000156172

Entrez Gene Symbol

CFAP418

Gene Synonym (7)

BBS21C8orf37CORD16FAP418FLJ30600MOT25RP64

Gene Description

Cilia and flagella associated protein 418

Chromosome

Position

95244913-95269201

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway5

Protein Function (4)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Eye disease
Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism

Cellular Component (6)

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence5

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	5	38225453 38731868 26801919 41201090 37922300

Sequence, Structure & Domains5

Sequences

Length

207

Mass

23,381

Sequence

MAEDLDELLDEVESKFCTPDLLRRGMVEQPKGCGGGTHSSDRNQAKAKETLRSTETFKKEDDLDSLINEILEEPNLDKKPSKLKSKSSGNTSVRASIEGLGKSCSPVYLGGSSIPCGIGTNISWRACDHLRCIACDFLVVSYDDYMWDKSCDYLFFRNNMPEFHKLKAKLIKKKGTRAYACQCSWRTIEEVTDLQTDHQLRWVCGKH

Domain & Motif Annotations

Compositional Bias

39..52; Basic and acidic residues

Region

1..75; Required for interaction with FAM161A; 26..52; Disordered

Clinical Relevance2

Disease Involvement (6)

Bardet-Biedl syndromeCiliopathyCone-rod dystrophyDisease variantObesityRetinitis pigmentosa

Antibody

HPA024198

Supporting Publications2

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available