Protein detail

VMA22

Vacuolar ATPase assembly protein VMA22 (Coiled-coil domain-containing protein 115)

Protein symbol
VMA22
UniProt ID
Q96NT0
EVMP score
0.38
Frequency
1
Transmembrane count
Protein classification
Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Vacuolar ATPase assembly protein VMA22 (Coiled-coil domain-containing protein 115)
Protein Class
Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins
Protein Function
  • Disease related genes
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
  • Predicted intracellular proteins
Ensembl
ENSG00000136710
Entrez Gene Symbol
CCDC115
Gene Synonym
ccp1FLJ30131MGC12981
Gene Description
Coiled-coil domain containing 115
Chromosome
2
Position
130337933-130342699
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cellsSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion
Function & Pathway
Protein Function
  • Disease related genes
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
  • Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

0 records.

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Size Exclusion ChromatographyMass spectrometry134265469
Sequence, Structure & Domains

Sequences

Length
180
Mass
19,761
Sequence
MAALDLRAELDSLVLQLLGDLEELEGKRTVLNARVEEGWLSLAKARYAMGAKSVGPLQYASHMEPQVCLHASEAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96NT0-1; Sequence=Displayed; Name=2; IsoId=Q96NT0-2; Sequence=VSP_056115, VSP_056116
Alternative Sequence
1..36; MAALDLRAELDSLVLQLLGDLEELEGKRTVLNARVE -> MGTPLDGGSRVPIGCPAKLRRVTRKKVAPDL (in isoform 2); 145..180; LQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA -> VLEAKKRKCFLERVIQCVVSPAAEQEAEDESCPEDWAAAVPAETSAKAI (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias
92..101; Basic and acidic residues
Coiled Coil
16..37; 153..176
Region
92..122; Disordered
Clinical Relevance
Disease Involvement
Congenital disorder of glycosylationDisease variant
Antibody
HPA034598
Interaction Protein
ENSG00000113643ENSG00000185344
Interaction Count
2
Interaction Dataset
intact_biogridbiogrid_opencell