Protein detail

VMA22

Vacuolar ATPase assembly protein VMA22 (Coiled-coil domain-containing protein 115)

Entry name
VMA22
UniProt ID
Q96NT0
EVMP confidence score
0.38
Supporting publications (n)
1
Transmembrane count
Protein classification
Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
Vacuolar ATPase assembly protein VMA22 (Coiled-coil domain-containing protein 115)
Protein Class (4)
Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins
Protein Function (3)
  • Disease related genes
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
  • Predicted intracellular proteins
Ensembl
ENSG00000136710
Entrez Gene Symbol
CCDC115
Gene Synonym (3)
ccp1FLJ30131MGC12981
Gene Description
Coiled-coil domain containing 115
Chromosome
2
Position
130337933-130342699
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization6
Tissue SpecificbrainCell SpecificAstrocytesBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cellsSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion
Function & Pathway6
Protein Function (3)
  • Disease related genes
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
  • Predicted intracellular proteins
Cellular Component (7)
Molecular Function (2)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence1

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Size Exclusion ChromatographyMass spectrometry134265469
Sequence, Structure & Domains8

Sequences

Length
180
Mass
19,761
Sequence
MAALDLRAELDSLVLQLLGDLEELEGKRTVLNARVEEGWLSLAKARYAMGAKSVGPLQYASHMEPQVCLHASEAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96NT0-1; Sequence=Displayed; Name=2; IsoId=Q96NT0-2; Sequence=VSP_056115, VSP_056116
Alternative Sequence
1..36; MAALDLRAELDSLVLQLLGDLEELEGKRTVLNARVE -> MGTPLDGGSRVPIGCPAKLRRVTRKKVAPDL (in isoform 2); 145..180; LQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA -> VLEAKKRKCFLERVIQCVVSPAAEQEAEDESCPEDWAAAVPAETSAKAI (in isoform 2)

Domain & Motif Annotations

Compositional Bias
92..101; Basic and acidic residues
Coiled Coil
16..37; 153..176
Region
92..122; Disordered
Clinical Relevance5
Disease Involvement (2)
Congenital disorder of glycosylationDisease variant
Antibody
HPA034598
Interaction Protein (2)
ENSG00000113643ENSG00000185344
Interaction Count
2
Interaction Dataset (2)
intact_biogridbiogrid_opencell
Supporting Publications1
PMIDTitleAbstract
15326289Identification and proteomic profiling of exosomes in human urine.No abstract available