Protein detail

LRRC7

Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1)

Entry name LRRC7	UniProt ID Q96NW7	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1)

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000033122

Entrez Gene Symbol

LRRC7

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Cell SpecificColonocytesSingle-Nuclei Brain Specificependymal cell

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (8)

Molecular Function (2)

Biological Process (3)

Reactome (14)

Page 1 of 2

Mediation Categories (4)

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence9

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
LRRC7	CAMK2A	Q9UQM7	S	1,439	phosphorylation	MIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper	SIGNOR:11160423 KEA:11160423 ProtMapper:11160423

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KCC2A	Q9UQM7	LRRC7	Q96NW7	Yes	No	No	MIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDHINTPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper	HINT:16120608 HINT:35830796 ProtMapper:11160423 HINT:11160423 HPRD:16120608 KEA:11160423 HPRD:11160423 SIGNOR:11160423

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27894104

Sequence, Structure & Domains15

Sequences

Length

1,537

Mass

172,581

Sequence

MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNTRVKVGSLQTTAKDAVHNSLWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMSDTFTDNWTDGSHYDNTGFVAEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYHDSNPNRSLSNVFSQIHCRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKVYNIPLENYASGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTYGSSKGPQQQKASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIAKDLISPRAYRGYPPMEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRRVNEPHELPPTDRYGRPPYRGGLDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTKSKFDHQELPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96NW7-1; Sequence=Displayed; Name=2; IsoId=Q96NW7-2; Sequence=VSP_010797; Name=3; Synonyms=LRRC7; IsoId=Q96NW7-3; Sequence=VSP_010795, VSP_010796

Alternative Sequence

178..179; KS -> NI (in isoform 3); 180..1537; Missing (in isoform 3); 1286..1332; Missing (in isoform 2)

3D Structural Models

Turn

1489..1493

Helix

1513..1522

Beta Strand

1445..1452; 1454..1456; 1458..1463; 1478..1484; 1499..1503; 1525..1533

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

663..676; Basic and acidic residues; 677..709; Polar residues; 790..804; Low complexity; 859..871; Low complexity; 872..882; Basic and acidic residues; 1243..1263; Basic and acidic residues; 1332..1354; Polar residues

Repeat

23..44; LRR 1; 47..68; LRR 2; 70..91; LRR 3; 93..114; LRR 4; 116..137; LRR 5; 139..161; LRR 6; 162..183; LRR 7; 185..206; LRR 8; 208..229; LRR 9; 231..253; LRR 10; 254..275; LRR 11; 277..298; LRR 12; 300..321; LRR 13; 323..344; LRR 14; 346..367; LRR 15; 369..391; LRR 16; 392..413; LRR 17

Domain (FT)

1445..1535; PDZ

Region

663..709; Disordered; 730..759; Disordered; 786..810; Disordered; 824..892; Disordered; 1136..1159; Disordered; 1234..1265; Disordered; 1331..1360; Disordered

Protein Families

LAP (LRR and PDZ) protein family

Sequence Similarities

Belongs to the LAP (LRR and PDZ) protein family.

Supporting Publications2

PMID	Title	Abstract
37565286	Tumor Necrosis Factor Alpha Preconditioned Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Enhance the Inhibition of Necroptosis of Acinar cells in Severe Acute Pancreatitis.	No abstract available
37752143	The oleic/palmitic acid imbalance in exosomes isolated from NAFLD patients induces necroptosis of liver cells via the elongase-6/RIP-1 pathway.	Administration of NAFLD-derived exosomes led to increased expression of Elongase 6 (ELOVL6), Stearoyl-CoA desaturase 1 (SCD1), Tumor necrosis factor α (TNF-α), Mixed-lineage-kinase-domain-like-protein (MLKL) and RIP-1 in the hepatocytes, comparable to mRNA levels in the hepatocytes of NAFLD patients reported in the Gene Expression Omnibus (GEO) database.