Protein detail
NECT4
Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4]
Protein symbol NECT4 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted membrane proteinsPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4]
Protein Class
Disease related genesHuman disease related genesPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Disease related genes
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
Transmembrane
350..370; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
LNIRnectin-4PRR4PVRL4
Gene Description
Nectin cell adhesion molecule 4
Chromosome
1
Position
161070998-161089558
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Single-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- Disease related genes
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
65 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| adhesion | adhesion | HGNC | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | HGNC | Yes | Yes | Yes | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| adherens_junction | adherens_junction | Ramilowski_location | No | Yes | Yes | Yes | No |
| adherens_junction | adherens_junction | Zhong2015 | No | Yes | Yes | Yes | No |
| adherens_junction | adherens_junction | OmniPath | No | Yes | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 39940641 |
Sequence, Structure & Domains
Sequences
Length
510
Mass
55,454
Sequence
MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96NY8-1; Sequence=Displayed; Name=2; IsoId=Q96NY8-2; Sequence=VSP_056819, VSP_056820
Alternative Sequence
1..266; Missing (in isoform 2); 412..436; Missing (in isoform 2)
3D Structural Models
Turn
84..86; 95..97
Helix
92..94; 119..121; 214..216
Beta Strand
38..43; 48..50; 62..69; 72..74; 77..83; 87..90; 112..114; 123..134; 136..146; 152..155; 165..177; 180..187; 190..197; 199..210; 220..226; 234..239
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
399..412; Basic and acidic residues
Domain (FT)
32..144; Ig-like V-type; 148..237; Ig-like C2-type 1; 248..331; Ig-like C2-type 2
Region
399..447; Disordered; 457..476; Disordered
Protein Families
Nectin family
Sequence Similarities
Belongs to the nectin family.
Clinical Relevance
Disease Involvement
Disease variantEctodermal dysplasia
Related Diseases
Biomarker
Phase 3; Phase 1/2; Approved
Antibody