Protein detail

NECT4

Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4]

Entry name NECT4	UniProt ID Q96NY8	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPredicted membrane proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4]

Protein Class (4)

Disease related genesHuman disease related genesPredicted membrane proteinsPredicted secreted proteins

Protein Function (3)

Disease related genes
Predicted secreted proteins
Human disease related genes:Congenital malformations:Congenital malformations of skin

Transmembrane

350..370; Helical

Transmembrane Count

Ensembl

ENSG00000143217

Entrez Gene Symbol

NECTIN4

Gene Synonym (4)

LNIRnectin-4PRR4PVRL4

Gene Description

Nectin cell adhesion molecule 4

Chromosome

Position

161070998-161089558

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Single-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway7

Protein Function (3)

Disease related genes
Predicted secreted proteins
Human disease related genes:Congenital malformations:Congenital malformations of skin

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

KEGG (3)

Reactome (4)

Mediation Categories (4)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence70

Ligand-Receptor Signaling (65)

65 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ligand	ligand	connectomeDB2020	Yes	No	Yes	Yes	No
ligand	ligand	CellCall	Yes	No	Yes	Yes	No
ligand	ligand	CellPhoneDB	Yes	No	Yes	Yes	No
ligand	ligand	GO_Intercell	Yes	No	Yes	Yes	No
ligand	ligand	OmniPath	Yes	No	Yes	Yes	No
receptor	receptor	talklr	No	Yes	Yes	Yes	No
receptor	receptor	scConnect	No	Yes	Yes	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	Yes	Yes	No
receptor	receptor	CellCall	No	Yes	Yes	Yes	No
receptor	receptor	iTALK	No	Yes	Yes	Yes	No

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Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
C6orf62 NECTIN4 PDSS1	Q5T2R2 Q96NY8 Q9GZU0	0:0:0	hu.MAP
C6orf62 NECTIN4 STING1	Q86WV6 Q96NY8 Q9GZU0	0:0:0	hu.MAP2
NECTIN4	Q96NY8	6	PDB	PDB:4jjhPDB:4frw
C6orf62 NECTIN4	Q96NY8 Q9GZU0	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	39940641

Sequence, Structure & Domains14

Sequences

Length

510

Mass

55,454

Sequence

MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96NY8-1; Sequence=Displayed; Name=2; IsoId=Q96NY8-2; Sequence=VSP_056819, VSP_056820

Alternative Sequence

1..266; Missing (in isoform 2); 412..436; Missing (in isoform 2)

3D Structural Models

Turn

84..86; 95..97

Helix

92..94; 119..121; 214..216

Beta Strand

38..43; 48..50; 62..69; 72..74; 77..83; 87..90; 112..114; 123..134; 136..146; 152..155; 165..177; 180..187; 190..197; 199..210; 220..226; 234..239

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

399..412; Basic and acidic residues

Domain (FT)

32..144; Ig-like V-type; 148..237; Ig-like C2-type 1; 248..331; Ig-like C2-type 2

Region

399..447; Disordered; 457..476; Disordered

Protein Families

Nectin family

Sequence Similarities

Belongs to the nectin family.

Clinical Relevance5

Disease Involvement (2)

Disease variantEctodermal dysplasia

Related Diseases (3)

Bladder cancer Solid tumour/cancer Ureteral cancer

Biomarker

Phase 3; Phase 1/2; Approved

Drugs (3)

ENFORTUMAB VEDOTIN-EJFV ENFORTUMAB VEDOTIN METHADONE HYDROCHLORIDE

Antibody

HPA010775

Supporting Publications1

PMID	Title	Abstract
38588410	PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways.	PVRL2 levels were found to be high in tumor cells and tumor-derived exosomes.