Protein detail
5NT1B
Cytosolic 5'-nucleotidase 1B (cN1B) (EC 3.1.3.5) (Autoimmune infertility-related protein) (Cytosolic 5'-nucleotidase IB) (cN-IB)
Entry name 5NT1B | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Cytosolic 5'-nucleotidase 1B (cN1B) (EC 3.1.3.5) (Autoimmune infertility-related protein) (Cytosolic 5'-nucleotidase IB) (cN-IB)
Protein Class (4)
EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
AIRPCN-IB
Gene Description
5'-nucleotidase, cytosolic IB
Chromosome
2
Position
18562871-18589572
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization3
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway7
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (2)
Molecular Function (4)
Biological Process (3)
KEGG (5)
Reactome (3)
Mediation Categories
Metabolism mediation
Relations & Evidence7
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry；Western blotting；Flow cytometry | 1 | 39940641 |
Sequence, Structure & Domains9
Sequences
Length
610
Mass
68,804
Sequence
MSQTSLKQKKNEPGMRSSKESLEAEKRKESDKTGVRLSNQMRRAVNPNHSLRCCPFQGHSSCRRCLCAAEGTALGPCHTIRIYIHMCLLWEQGQQITMMRGSQESSLRKTDSRGYLVRSQWSRISRSPSTKAPSIDEPRSRNTSAKLPSSSTSSRTPSTSPSLHDSSPPPLSGQPSLQPPASPQLPRSLDSRPPTPPEPDPGSRRSTKMQENPEAWAQGIVREIRQTRDSQPLEYSRTSPTEWKSSSQRRGIYPASTQLDRNSLSEQQQQQREDEDDYEAAYWASMRSFYEKNPSCSRPWPPKPKNAITIALSSCALFNMVDGRKIYEQEGLEKYMEYQLTNENVILTPGPAFRFVKALQYVNARLRDLYPDEQDLFDIVLMTNNHAQVGVRLINSVNHYGLLIDRFCLTGGKDPIGYLKAYLTNLYIAADSEKVQEAIQEGIASATMFDGAKDMAYCDTQLRVAFDGDAVLFSDESEHFTKEHGLDKFFQYDTLCESKPLAQGPLKGFLEDLGRLQKKFYAKNERLLCPIRTYLVTARSAASSGARVLKTLRRWGLEIDEALFLAGAPKSPILVKIRPHIFFDDHMFHIEGAQRLGSIAAYGFNKKFSS
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=CN-Ib alpha; IsoId=Q96P26-1; Sequence=Displayed; Name=2; IsoId=Q96P26-2; Sequence=VSP_010201; Name=3; IsoId=Q96P26-3; Sequence=VSP_010202; Name=4; IsoId=Q96P26-4; Sequence=VSP_010203
Alternative Sequence
1..208; Missing (in isoform 3); 41..100; Missing (in isoform 2); 596..610; LGSIAAYGFNKKFSS -> KSLGWMS (in isoform 4)
Domain & Motif Annotations
Compositional Bias
9..34; Basic and acidic residues; 119..132; Polar residues; 148..166; Low complexity; 167..183; Pro residues; 236..265; Polar residues
Region
1..34; Disordered; 101..277; Disordered
Protein Families
5'-nucleotidase type 3 family
Sequence Similarities
Belongs to the 5'-nucleotidase type 3 family.
Clinical Relevance1
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 30408591 | Portrait of blood-derived extracellular vesicles in patients with Parkinson's disease. | No abstract available |