Protein detail

DCBD2

Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein)

Entry name DCBD2	UniProt ID Q96PD2	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein)

Protein Class (2)

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

529..549; Helical

Transmembrane Count

Ensembl

ENSG00000057019

Entrez Gene Symbol

DCBLD2

Gene Synonym (2)

CLCP1ESDN

Gene Description

Discoidin, CUB and LCCL domain containing 2

Chromosome

Position

98795941-98901695

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue Specificlymphoid tissueCell SpecificPlateletsSingle-Nuclei Brain SpecificfibroblastBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cells

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence73

Enzyme-Mediated Modification (33)

33 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
DCBLD2	ABL1	P00519	Y	750	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	Y	715	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	Y	565	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	T	756	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	S	600	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	S	598	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	Y	655	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	S	760	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	Y	649	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	Y	597	phosphorylation	PhosphoSite

Page 1 of 4Next

Ligand-Receptor Signaling (37)

37 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
semaphorin	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No

Page 1 of 4Next

Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FYN	P06241	DCBD2	Q96PD2	Yes	Yes	No	PhosphoSite_norefSIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:23770091
ABL1	P00519	DCBD2	Q96PD2	Yes	No	No	PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:32606017 PhosphoSite:23770091

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	8	38113368 37322475 40189497 41068253 32854315 41307968 27821849 38207106

Sequence, Structure & Domains8

Sequences

Length

775

Mass

85,035

Sequence

MASRAVVRARRCPQCPQVRAAAAAPAWAALPLSRSLPPCSNSSSFSMPLFLLLLLVLLLLLEDAGAQQGDGCGHTVLGPESGTLTSINYPQTYPNSTVCEWEIRVKMGERVRIKFGDFDIEDSDSCHFNYLRIYNGIGVSRTEIGKYCGLGLQMNHSIESKGNEITLLFMSGIHVSGRGFLASYSVIDKQDLITCLDTASNFLEPEFSKYCPAGCLLPFAEISGTIPHGYRDSSPLCMAGVHAGVVSNTLGGQISVVISKGIPYYESSLANNVTSVVGHLSTSLFTFKTSGCYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLKKPGPPWAAFATDEYQWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKWTVYREPGVEQDKIFQGNKDYHQDVRNNFLPPIIARFIRVNPTQWQQKIAMKMELLGCQFIPKGRPPKLTQPPPPRNSNDLKNTTAPPKIAKGRAPKFTQPLQPRSSNEFPAQTEQTTASPDIRNTTVTPNVTKDVALAAVLVPVLVMVLTTLILILVCAWHWRNRKKKTEGTYDLPYWDRAGWWKGMKQFLPAKAVDHEETPVRYSSSEVNHLSPREVTTVLQADSAEYAQPLVGGIVGTLHQRSTFKPEEGKEAGYADLDPYNSPGQEVYHAYAEPLPITGPEYATPIIMDMSGHPTTSVGQPSTSTFKATGNQPPPLVGTYNTLLSRTDSCSSAQAQYDTPKAGKPGLPAPDELVYQVPQSTQEVSGAGRDGECDVFKEIL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96PD2-1; Sequence=Displayed; Name=2; IsoId=Q96PD2-2; Sequence=VSP_010715

Alternative Sequence

574; G -> GFYLMVSLACRHNEG (in isoform 2)

Domain & Motif Annotations

Compositional Bias

468..477; Polar residues; 491..517; Polar residues; 690..706; Polar residues

Domain (FT)

72..186; CUB; 187..285; LCCL; 292..449; F5/8 type C

Region

454..517; Disordered; 690..710; Disordered

Clinical Relevance1

Antibody

HPA016909

Supporting Publications1

PMID	Title	Abstract
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No abstract available