Protein detail

DCBD2

Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein)

Protein symbol DCBD2	UniProt ID Q96PD2	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein)

Protein Class

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

529..549; Helical

Transmembrane Count

Ensembl

ENSG00000057019

Entrez Gene Symbol

DCBLD2

Gene Synonym

CLCP1ESDN

Gene Description

Discoidin, CUB and LCCL domain containing 2

Chromosome

Position

98795941-98901695

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificPlateletsSingle-Nuclei Brain SpecificfibroblastBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

33 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
DCBLD2	ABL1	P00519	Y	621	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	T	679	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	Y	677	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	S	618	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	Y	666	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	T	593	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	T	714	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	Y	663	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	S	599	phosphorylation	PhosphoSite
DCBLD2	FYN	P06241	Y	750	phosphorylation	PhosphoSite

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Ligand-Receptor Signaling

37 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FYN	P06241	DCBD2	Q96PD2	Yes	Yes	No	PhosphoSite_norefSIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:23770091
ABL1	P00519	DCBD2	Q96PD2	Yes	No	No	PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:32606017 PhosphoSite:23770091

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	8	38113368 37322475 40189497 41068253 32854315 41307968 27821849 38207106

Sequence, Structure & Domains

Sequences

Length

775

Mass

85,035

Sequence

MASRAVVRARRCPQCPQVRAAAAAPAWAALPLSRSLPPCSNSSSFSMPLFLLLLLVLLLLLEDAGAQQGDGCGHTVLGPESGTLTSINYPQTYPNSTVCEWEIRVKMGERVRIKFGDFDIEDSDSCHFNYLRIYNGIGVSRTEIGKYCGLGLQMNHSIESKGNEITLLFMSGIHVSGRGFLASYSVIDKQDLITCLDTASNFLEPEFSKYCPAGCLLPFAEISGTIPHGYRDSSPLCMAGVHAGVVSNTLGGQISVVISKGIPYYESSLANNVTSVVGHLSTSLFTFKTSGCYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLKKPGPPWAAFATDEYQWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKWTVYREPGVEQDKIFQGNKDYHQDVRNNFLPPIIARFIRVNPTQWQQKIAMKMELLGCQFIPKGRPPKLTQPPPPRNSNDLKNTTAPPKIAKGRAPKFTQPLQPRSSNEFPAQTEQTTASPDIRNTTVTPNVTKDVALAAVLVPVLVMVLTTLILILVCAWHWRNRKKKTEGTYDLPYWDRAGWWKGMKQFLPAKAVDHEETPVRYSSSEVNHLSPREVTTVLQADSAEYAQPLVGGIVGTLHQRSTFKPEEGKEAGYADLDPYNSPGQEVYHAYAEPLPITGPEYATPIIMDMSGHPTTSVGQPSTSTFKATGNQPPPLVGTYNTLLSRTDSCSSAQAQYDTPKAGKPGLPAPDELVYQVPQSTQEVSGAGRDGECDVFKEIL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96PD2-1; Sequence=Displayed; Name=2; IsoId=Q96PD2-2; Sequence=VSP_010715

Alternative Sequence

574; G -> GFYLMVSLACRHNEG (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

468..477; Polar residues; 491..517; Polar residues; 690..706; Polar residues

Domain (FT)

72..186; CUB; 187..285; LCCL; 292..449; F5/8 type C

Region

454..517; Disordered; 690..710; Disordered

Clinical Relevance

Antibody

HPA016909