Protein detail

DCBD2

Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein)

Protein symbol DCBD2	UniProt ID Q96PD2	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Discoidin, CUB and LCCL domain-containing protein 2 (CUB, LCCL and coagulation factor V/VIII-homology domains protein 1) (Endothelial and smooth muscle cell-derived neuropilin-like protein)

Protein Class

Predicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

529..549; Helical

Transmembrane Count

Ensembl

ENSG00000057019

Entrez Gene Symbol

DCBLD2

Gene Synonym

CLCP1ESDN

Gene Description

Discoidin, CUB and LCCL domain containing 2

Chromosome

Position

98795941-98901695

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificPlateletsSingle-Nuclei Brain SpecificfibroblastBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

33 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
DCBLD2	ABL1	P00519	Y	621	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	T	679	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	Y	677	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	S	618	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	Y	666	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	T	593	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	T	714	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	Y	663	phosphorylation	PhosphoSite
DCBLD2	ABL1	P00519	S	599	phosphorylation	PhosphoSite
DCBLD2	FYN	P06241	Y	750	phosphorylation	PhosphoSite

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Ligand-Receptor Signaling

37 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	Baccin2019	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	EMBRACE	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FYN	P06241	DCBD2	Q96PD2	Yes	Yes	No	PhosphoSite_norefSIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:23770091
ABL1	P00519	DCBD2	Q96PD2	Yes	No	No	PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:32606017 PhosphoSite:23770091

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	8	38113368 37322475 40189497 41068253 32854315 41307968 27821849 38207106

Sequence, Structure & Domains

Sequences

Length

775

Mass

85,035

Sequence

MASRAVVRARRCPQCPQVRAAAAAPAWAALPLSRSLPPCSNSSSFSMPLFLLLLLVLLLLLEDAGAQQGDGCGHTVLGPESGTLTSINYPQTYPNSTVCEWEIRVKMGERVRIKFGDFDIEDSDSCHFNYLRIYNGIGVSRTEIGKYCGLGLQMNHSIESKGNEITLLFMSGIHVSGRGFLASYSVIDKQDLITCLDTASNFLEPEFSKYCPAGCLLPFAEISGTIPHGYRDSSPLCMAGVHAGVVSNTLGGQISVVISKGIPYYESSLANNVTSVVGHLSTSLFTFKTSGCYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLKKPGPPWAAFATDEYQWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKWTVYREPGVEQDKIFQGNKDYHQDVRNNFLPPIIARFIRVNPTQWQQKIAMKMELLGCQFIPKGRPPKLTQPPPPRNSNDLKNTTAPPKIAKGRAPKFTQPLQPRSSNEFPAQTEQTTASPDIRNTTVTPNVTKDVALAAVLVPVLVMVLTTLILILVCAWHWRNRKKKTEGTYDLPYWDRAGWWKGMKQFLPAKAVDHEETPVRYSSSEVNHLSPREVTTVLQADSAEYAQPLVGGIVGTLHQRSTFKPEEGKEAGYADLDPYNSPGQEVYHAYAEPLPITGPEYATPIIMDMSGHPTTSVGQPSTSTFKATGNQPPPLVGTYNTLLSRTDSCSSAQAQYDTPKAGKPGLPAPDELVYQVPQSTQEVSGAGRDGECDVFKEIL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96PD2-1; Sequence=Displayed; Name=2; IsoId=Q96PD2-2; Sequence=VSP_010715

Alternative Sequence

574; G -> GFYLMVSLACRHNEG (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

468..477; Polar residues; 491..517; Polar residues; 690..706; Polar residues

Domain (FT)

72..186; CUB; 187..285; LCCL; 292..449; F5/8 type C

Region

454..517; Disordered; 690..710; Disordered

Clinical Relevance

Antibody

HPA016909