Protein detail
AGRA2
Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5)
Entry name AGRA2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Adhesion G protein-coupled receptor A2 (G-protein coupled receptor 124) (Tumor endothelial marker 5)
Protein Class (3)
G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- G-protein coupled receptors:Family 2 (B) receptors
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
772..792; Helical; Name=1; 808..828; Helical; Name=2; 833..853; Helical; Name=3; 887..907; Helical; Name=4; 925..945; Helical; Name=5; 1020..1040; Helical; Name=6; 1048..1068; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym (6)
DKFZp434C211DKFZp434J0911FLJ14390GPR124KIAA1531TEM5
Gene Description
Adhesion G protein-coupled receptor A2
Chromosome
8
Position
37784191-37844896
Supporting publications (n)
1
EVMP confidence score
0.50
Function & Pathway5
Protein Function (3)
- G-protein coupled receptors:Family 2 (B) receptors
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (6)
Molecular Function (2)
Biological Process (3)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence58
Ligand-Receptor Signaling (57)
57 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| 7tm_b | receptor | HPMR | No | Yes | No | Yes | No |
| latrophilin_lectomedin_7tm_b | receptor | HPMR | No | Yes | No | Yes | No |
| gpcr | receptor | Surfaceome | No | Yes | No | Yes | No |
| adhesion | receptor | Surfaceome | No | Yes | No | Yes | No |
| class_b2_adhesion | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_b2_adhesion_adhesion | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_b2_adhesion_adhesion_adgra | receptor | GPCRdb | No | Yes | No | Yes | No |
| adhesion_gpcr | receptor | ICELLNET | No | Yes | No | Yes | No |
| wnt_pathway | receptor | ICELLNET | No | Yes | No | Yes | No |
| cell_adhesion | receptor | ICELLNET | No | Yes | No | Yes | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 34265469 |
Sequence, Structure & Domains13
Sequences
Length
1,338
Mass
142,647
Sequence
MGAGGRRMRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETTV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96PE1-1; Sequence=Displayed; Name=2; IsoId=Q96PE1-2; Sequence=VSP_010076; Name=3; IsoId=Q96PE1-3; Sequence=VSP_036215
Alternative Sequence
186..1338; Missing (in isoform 3); 537..753; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
578..587; Pro residues; 981..991; Low complexity; 1088..1098; Pro residues; 1111..1126; Low complexity; 1168..1190; Basic residues; 1223..1237; Polar residues; 1264..1273; Low complexity; 1275..1292; Basic and acidic residues
Repeat
82..106; LRR 1; 107..130; LRR 2; 131..154; LRR 3; 156..178; LRR 4
Motif
362..364; RGD; 1335..1338; PDZ-binding
Domain (CC)
The leucine-rich repeats (LRRs) are important for potentiation of Wnt7 signaling.; DOMAIN: The RGD motif is involved in integrin ITGAV:ITGB3 binding.
Domain (FT)
190..240; LRRCT; 247..344; Ig-like; 594..759; GAIN-B
Region
565..591; Disordered; 710..759; GPS; 958..991; Disordered; 1088..1126; Disordered; 1150..1196; Disordered; 1218..1309; Disordered
Protein Families (2)
- G-protein coupled receptor 2 family
- Adhesion G-protein coupled receptor (ADGR) subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Clinical Relevance4
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 27605433 | Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo. | No abstract available |