Protein detail

KLHL5

Kelch-like protein 5

Protein symbol
KLHL5
UniProt ID
EVMP score
0.38
Frequency
1
Transmembrane count
Protein classification
Plasma proteinsPredicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Kelch-like protein 5
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Entrez Gene Symbol
Gene Description
Kelch like family member 5
Chromosome
4
Position
39045039-39126857
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificOligodendrocytes
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

9 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
transmembrane_predictedtransmembraneOmniPathNoNoNoNoNo
transmembranetransmembraneRamilowski_locationNoNoNoNoNo
transmembranetransmembraneOmniPathNoNoNoNoNo
transmembrane_sosuitransmembrane_predictedAlmen2009NoNoNoNoNo
transmembrane_tmhmmtransmembrane_predictedAlmen2009NoNoNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CRL3 E3 ubiquitin ligase complexKLHL5 variantCUL3KLHL5RBX1P62877Q13618Q96PQ72:2:2ComplexPortalintact:EBI-44455107355807992924957024959344348385421475529231652307

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyR SequencingMass spectrometry139940641
Sequence, Structure & Domains

Sequences

Length
755
Mass
84,457
Sequence
MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQLDFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=KLHL5a; IsoId=Q96PQ7-1; Sequence=Displayed; Name=2; IsoId=Q96PQ7-2; Sequence=VSP_008619; Name=3; IsoId=Q96PQ7-3; Sequence=VSP_008620; Name=4; Synonyms=KLHL5b; IsoId=Q96PQ7-4; Sequence=VSP_045227; Name=5; IsoId=Q96PQ7-5; Sequence=VSP_047111; Name=6; IsoId=Q96PQ7-6; Sequence=VSP_047112
Alternative Sequence
1..187; Missing (in isoform 5); 1..46; Missing (in isoform 6); 174..234; Missing (in isoform 4); 739..755; APLCLGRAGACVVTVKL -> WHSCFIITLTLFLLKQFLW (in isoform 2); 739..755; APLCLGRAGACVVTVKL -> FSHTFEDSKDHLVAIKQTIWRQNSLSEEFRSH (in isoform 3)

3D Structural Models

Domain & Motif Annotations

Compositional Bias
158..168; Acidic residues; 169..184; Low complexity
Repeat
468..514; Kelch 1; 515..561; Kelch 2; 563..608; Kelch 3; 609..655; Kelch 4; 657..708; Kelch 5; 709..754; Kelch 6
Domain (FT)
220..287; BTB
Region
152..184; Disordered
Clinical Relevance
Interaction Protein
ENSG00000036257
Interaction Count
1
Interaction Dataset
intact_biogrid