Protein detail
AQP10
Aquaporin-10 (AQP-10) (Aquaglyceroporin-10) (Small intestine aquaporin)
Protein symbol AQP10 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 6 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Aquaporin-10 (AQP-10) (Aquaglyceroporin-10) (Small intestine aquaporin)
Protein Class
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Transporter channels and pores
Transmembrane
23..41; Helical; Name=1; 56..75; Helical; Name=2; 97..121; Helical; Name=3; 159..176; Helical; Name=4; 189..205; Helical; Name=5; 242..262; Helical; Name=6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Description
Aquaporin 10
Chromosome
1
Position
154321090-154325325
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineCell SpecificAlveolar cells type 1
Function & Pathway
Protein Function
Transporters:Transporter channels and pores
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| aquaporins | transporter | Surfaceome | No | Yes | No | No | No |
| ion_channel | ion_channel | Almen2009 | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | OPM | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
301
Mass
31,763
Sequence
MVFTQAPAEIMGHLRIRSLLARQCLAEFLGVFVLMLLTQGAVAQAVTSGETKGNFFTMFLAGSLAVTIAIYVGGNVSGAHLNPAFSLAMCIVGRLPWVKLPIYILVQLLSAFCASGATYVLYHDALQNYTGGNLTVTGPKETASIFATYPAPYLSLNNGFLDQVLGTGMLIVGLLAILDRRNKGVPAGLEPVVVGMLILALGLSMGANCGIPLNPARDLGPRLFTYVAGWGPEVFSAGNGWWWVPVVAPLVGATVGTATYQLLVALHHPEGPEPAQDLVSAQHKASELETPASAQMLECKL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96PS8-1; Sequence=Displayed; Name=2; IsoId=Q96PS8-2; Sequence=VSP_010211
Alternative Sequence
236..301; SAGNGWWWVPVVAPLVGATVGTATYQLLVALHHPEGPEPAQDLVSAQHKASELETPASAQMLECKL -> RWETDSPGAGLHSPSSAKGSVPGSTALCL (in isoform 2)
3D Structural Models
Turn
48..50; 207..209; 228..230
Helix
19..47; 55..72; 83..91; 97..99; 100..121; 123..130; 143..145; 156..178; 190..205; 215..227; 233..240; 241..243; 244..267
Beta Strand
136..138
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Motif
82..84; NPA 1; 214..216; NPA 2
Domain (CC)
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Protein Families
MIP/aquaporin (TC 1.A.8) family
Sequence Similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family.