Protein detail

PLIN4

Perilipin-4 (Adipocyte protein S3-12)

Entry name
PLIN4
UniProt ID
Q96Q06
EVMP confidence score
0.40
Supporting publications (n)
2
Transmembrane count
Protein classification
Metabolic proteinsPlasma proteinsPredicted intracellular proteins
Basic Information
Protein Names
Perilipin-4 (Adipocyte protein S3-12)
Protein Class (3)
Metabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000167676
Entrez Gene Symbol
PLIN4
Gene Synonym (2)
KIAA1881S3-12
Gene Description
Perilipin 4
Chromosome
19
Position
4502192-4518486
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
PLIN4 fluorescence
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (3)
Biological Process (3)
KEGG
hsa03320 PPAR signaling pathway
Reactome (3)
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence7

Ligand-Receptor Signaling (6)

6 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
plasma_membraneplasma_membraneUniProt_location
plasma_membraneplasma_membraneOmniPath

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyPolymer PrecipitationSmall R sequencing (Illumi HiSeq 2000 (Solexa)Mass spectrometry24022245734980157
Sequence, Structure & Domains

Sequences

Length
1,371
Mass
135,892
Sequence
MSAPDEGRRDPPKPKGKTLGSFFGSLPGFSSARNLVANAHSSARARPAADPTGAPAAEAAQPQAQVAAHPEQTAPWTEKELQPSEKMVSGAKDLVCSKMSRAKDAVSSGVASVVDVAKGVVQGGLDTTRSALTGTKEVVSSGVTGAMDMAKGAVQGGLDTSKAVLTGTKDTVSTGLTGAVNVAKGTVQAGVDTTKTVLTGTKDTVTTGVMGAVNLAKGTVQTGVETSKAVLTGTKDAVSTGLTGAVNVARGSIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTSKTVLTGTKDTVCSGVTGAMNVAKGTIQTGVDTTKTVLTGTKNTVCSGVTGAVNLAKEAIQGGLDTTKSMVMGTKDTMSTGLTGAANVAKGAMQTGLNTTQNIATGTKDTVCSGVTGAMNLARGTIQTGVDTTKIVLTGTKDTVCSGVTGAANVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNVAKGTVQTGVDTTKTVLTGTKDTVCSGVTSAVNVAKGAVQGGLDTTKSVVIGTKDTMSTGLTGAANVAKGAVQTGVDTAKTVLTGTKDTVTTGLVGAVNVAKGTVQTGMDTTKTVLTGTKDTIYSGVTSAVNVAKGAVQTGLKTTQNIATGTKNTFGSGVTSAVNVAKGAAQTGVDTAKTVLTGTKDTVTTGLMGAVNVAKGTVQTSVDTTKTVLTGTKDTVCSGVTGAANVAKGAIQGGLDTTKSVLTGTKDAVSTGLTGAVKLAKGTVQTGMDTTKTVLTGTKDAVCSGVTGAANVAKGAVQMGVDTAKTVLTGTKDTVCSGVTGAANVAKGAVQTGLKTTQNIATGTKNTLGSGVTGAAKVAKGAVQGGLDTTKSVLTGTKDAVSTGLTGAVNLAKGTVQTGVDTSKTVLTGTKDTVCSGVTGAVNVAKGTVQTGVDTAKTVLSGAKDAVTTGVTGAVNVAKGTVQTGVDASKAVLMGTKDTVFSGVTGAMSMAKGAVQGGLDTTKTVLTGTKDAVSAGLMGSGNVATGATHTGLSTFQNWLPSTPATSWGGLTSSRTTDNGGEQTALSPQEAPFSGISTPPDVLSVGPEPAWEAAATTKGLATDVATFTQGAAPGREDTGLLATTHGPEEAPRLAMLQNELEGLGDIFHPMNAEEQAQLAASQPGPKVLSAEQGSYFVRLGDLGPSFRQRAFEHAVSHLQHGQFQARDTLAQLQDCFRLIEKAQQAPEGQPRLDQGSGASAEDAAVQEERDAGVLSRVCGLLRQLHTAYSGLVSSLQGLPAELQQPVGRARHSLCELYGIVASAGSVEELPAERLVQSREGVHQAWQGLEQLLEGLQHNPPLSWLVGPFALPAGGQ

Domain & Motif Annotations

Compositional Bias
1..13; Basic and acidic residues; 44..72; Low complexity; 1060..1083; Polar residues
Repeat
109..141; 1; 142..174; 2; 175..207; 3; 208..240; 4; 241..273; 5; 274..306; 6; 307..339; 7; 340..372; 8; 373..405; 9; 406..438; 10; 439..471; 11; 472..504; 12; 505..537; 13; 538..570; 14; 571..603; 15; 604..636; 16; 637..669; 17; 670..702; 18; 703..735; 19; 736..768; 20; 769..801; 21; 802..834; 22; 835..867; 23; 868..900; 24; 901..933; 25; 934..966; 26; 967..999; 27
Region
1..22; Disordered; 37..86; Disordered; 109..999; 27 X 33 AA approximate tandem repeat; 1060..1093; Disordered; 1240..1260; Disordered
Protein Families
Perilipin family
Sequence Similarities
Belongs to the perilipin family.
Clinical Relevance
Antibody (2)
HPA044682HPA054657
Supporting Publications2
PMIDTitleRelated sentences
32301581Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues.Extracellular vesicles (EVs) from human Alzheimer's disease (AD) biospecimens contain amyloid beta (Aβ) peptide and tau.
32384937Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.No related sentences available