Protein detail

CIB3

Calcium and integrin-binding family member 3 (Kinase-interacting protein 3) (KIP 3)

Protein symbol CIB3	UniProt ID Q96Q77	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Calcium and integrin-binding family member 3 (Kinase-interacting protein 3) (KIP 3)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000141977

Entrez Gene Symbol

CIB3

Gene Synonym

KIP3

Gene Description

Calcium and integrin binding family member 3

Chromosome

Position

16161368-16173525

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificcervixCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificdeep-layer intratelencephalic

Function & Pathway

Protein Function

Predicted intracellular proteins

Molecular Function

Biological Process

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CIB3	Q96Q77	2	PDB	PDB:6wu5PDB:6wu7

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion Chromatography	Mass spectrometry	4	39940641 36398564 34817906 38321535

Sequence, Structure & Domains

Sequences

Length

187

Mass

21,802

Sequence

MGNKQTVFTHEQLEAYQDCTFFTRKEIMRLFYRYQDLAPQLVPLDYTTCPDVKVPYELIGSMPELKDNPFRQRIAQVFSEDGDGHMTLDNFLDMFSVMSEMAPRDLKAYYAFKIYDFNNDDYICAWDLEQTVTKLTRGGLSAEEVSLVCEKVLDEADGDHDGRLSLEDFQNMILRAPDFLSTFHIRI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96Q77-1; Sequence=Displayed; Name=2; IsoId=Q96Q77-2; Sequence=VSP_055509

Alternative Sequence

18..66; Missing (in isoform 2)

3D Structural Models

Turn

39..41; 63..67; 136..138

Helix

10..19; 24..37; 46..48; 56..60; 71..78; 88..98; 104..115; 125..135; 142..156; 166..174; 181..183

Beta Strand

82..84; 120..123; 160..164

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Domain (FT)

66..101; EF-hand 1; 103..138; EF-hand 2; 144..179; EF-hand 3

Clinical Relevance

Antibody

HPA043553 HPA043995