Protein detail

GSDMA

Gasdermin-A (Gasdermin-1) [Cleaved into: Gasdermin-A, N-terminal (GSDMA-NT); Gasdermin-A, C-terminal (GSDMA-CT)]

Entry name GSDMA	UniProt ID Q96QA5	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 4	Protein classification Essential proteinsPredicted intracellular proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Gasdermin-A (Gasdermin-1) [Cleaved into: Gasdermin-A, N-terminal (GSDMA-NT); Gasdermin-A, C-terminal (GSDMA-CT)]

Protein Class (3)

Essential proteinsPredicted intracellular proteinsTransporters

Protein Function (2)

Transporters:Transporter channels and pores
Predicted intracellular proteins

Transmembrane

78..95; Beta stranded; 99..120; Beta stranded; 163..179; Beta stranded; 183..197; Beta stranded

Transmembrane Count

Ensembl

ENSG00000167914

Entrez Gene Symbol

GSDMA

Gene Synonym (3)

FLJ39120GSDMGSDM1

Gene Description

Gasdermin A

Chromosome

Position

39953263-39977768

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway4

Protein Function (2)

Transporters:Transporter channels and pores
Predicted intracellular proteins

Cellular Component (4)

Molecular Function (5)

Mediation Categories

Other mediation

Relations & Evidence10

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	AZGP1 GSDMA TGM3	P25311 Q08188 Q96QA5	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	1	32795414

Sequence, Structure & Domains7

Sequences

Length

445

Mass

49,365

Sequence

MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVRTDYTLLDVLEPGSSPSDPTDTGNFGFKNMLDTRVEGDVDVPKTVKVKGTAGLSQNSTLEVQTLSVAPKALETVQERKLAADHPFLKEMQDQGENLYVVMEVVETVQEVTLERAGKAEACFSLPFFAPLGLQGSINHKEAVTIPKGCVLAFRVRQLMVKGKDEWDIPHICNDNMQTFPPGEKSGEEKVILIQASDVGDVHEGFRTLKEEVQRETQQVEKLSRVGQSSLLSSLSKLLGKKKELQDLELALEGALDKGHEVTLEALPKDVLLSKEAVGAILYFVGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLLDKEGVFPLQPELLSSLGDEELTLTEALVGLSGLEVQRSGPQYMWDPDTLPRLCALYAGLSLLQQLTKAS

Domain & Motif Annotations

Domain (CC)

Intramolecular interactions between N- and C-terminal domains are important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.

Region

1..251; Triggers pyroptosis

Protein Families

Gasdermin family

Sequence Similarities

Belongs to the gasdermin family.

Clinical Relevance1

Antibody (2)

HPA023313 HPA064826

Supporting Publications1

PMID	Title	Abstract
37440012	Decoding Race and Age-Related Macular Degeneration: GPR 143 Activity Is the Key.	GPR143 activity upregulates PEDF and downregulates both VEGF and exosomes; all of which reduce the angiogenic potential in the retina.