Protein detail
S38A2
Sodium-coupled neutral amino acid symporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2)
Entry name S38A2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 11 | Protein classification Essential proteinsFDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Sodium-coupled neutral amino acid symporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2)
Protein Class (5)
Essential proteinsFDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
Transmembrane
77..96; Helical; 103..123; Helical; 159..177; Helical; 189..209; Helical; 218..238; Helical; 293..313; Helical; 330..350; Helical; 372..392; Helical; 414..434; Helical; 437..457; Helical; 473..495; Helical
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
ATA2KIAA1382SAT2SNAT2
Gene Description
Solute carrier family 38 member 2
Chromosome
12
Position
46358188-46372773
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue SpecificlungCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cell
Function & Pathway7
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
Cellular Component (7)
Molecular Function (9)
- GO:0005283 amino acid:sodium symporter activity
- GO:0005295 neutral L-amino acid:sodium symporter activity
- GO:0005298 proline:sodium symporter activity
- GO:0005515 protein binding
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015172 acidic amino acid transmembrane transporter activity
- GO:0015186 L-glutamine transmembrane transporter activity
- GO:0015194 L-serine transmembrane transporter activity
- GO:0015655 alanine:sodium symporter activity
Biological Process (3)
KEGG (3)
Reactome (7)
- R-hsa-210500 glutamate neurotransmitter release cycle
- R-hsa-112316 neuronal system
- R-hsa-112310 neurotransmitter release cycle
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9958863 slc mediated transport of amino acids
- R-hsa-112315 transmission across chemical synapses
- R-hsa-382551 transport of small molecules
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence27
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| apc | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| slc38 | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
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Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ATP6AP2MITD1OSTM1RABL3SLC38A2 | O75787Q5HYI8Q86WC4Q8WV92Q96QD8 | 0:0:0:0:0 | hu.MAP2 | |||
| ERLIN2KRT7MCUSLC38A2 | O94905P08729Q8NE86Q96QD8 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_196 | ||
| COX5ACOX5BMCUSLC38A2 | P10606P20674Q8NE86Q96QD8 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_218 | ||
| PIEZO1SLC38A2 | Q92508Q96QD8 | 0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 1 | 37432984 |
Sequence, Structure & Domains9
Sequences
Length
506
Mass
56,026
Sequence
MKKAEMGRFSISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYETEFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96QD8-1; Sequence=Displayed; Name=2; IsoId=Q96QD8-2; Sequence=VSP_029553, VSP_029554
Alternative Sequence
1..100; Missing (in isoform 2); 101..105; IALFI -> MKQNL (in isoform 2)
Domain & Motif Annotations
Domain (CC)
The extracellular C-terminal domain controls the voltage dependence for amino acid transports activity.
Region
1..96; Regulates protein turnover upon amino acid deprivation; 1..23; Disordered
Protein Families
Amino acid/polyamine transporter 2 family
Sequence Similarities
Belongs to the amino acid/polyamine transporter 2 family.
Clinical Relevance4
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 25776846 | Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens. | No abstract available |