Protein detail
TRPM7
Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form]
Entry name TRPM7 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 6 | Protein classification Disease related genesEnzymesEssential proteinsFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7) [Cleaved into: TRPM7 kinase, cleaved form (M7CK); TRPM7 channel, cleaved form]
Protein Class
Disease related genesEnzymesEssential proteinsFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels
Protein Function
- Voltage-gated ion channels:Transient Receptor Potential Channels
- Predicted intracellular proteins
- Kinases:Atypical kinases
- ENZYME proteins:Transferases
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Enzymes
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
851..876; Helical; Name=1; 883..904; Helical; Name=2; 924..943; Helical; Name=3; 957..980; Helical; Name=4; 1000..1023; Helical; Name=5; 1070..1098; Helical; Name=6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
CHAK1LTRPC7TRP-PLIK
Gene Description
Transient receptor potential cation channel subfamily M member 7
Chromosome
15
Position
50552473-50686797
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEsophageal apical cellsSingle-Nuclei Brain SpecificpericyteBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Voltage-gated ion channels:Transient Receptor Potential Channels
- Predicted intracellular proteins
- Kinases:Atypical kinases
- ENZYME proteins:Transferases
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Enzymes
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
- GO:0003779 actin binding
- GO:0004674 protein serine/threonine kinase activity
- GO:0005262 calcium channel activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0015095 magnesium ion transmembrane transporter activity
- GO:0017022 myosin binding
- GO:0044024 histone H2AS1 kinase activity
- GO:0046872 metal ion binding
- GO:0106310 protein serine kinase activity
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| TRPM7 | TRPM6 | Q9BX84 | T | 1,482 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:26563869 |
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| peripheral | peripheral | UniProt_topology | No | No | No | No | No |
| peripheral | peripheral | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TRPM6 | Q9BX84 | TRPM7 | Q96QT4 | Yes | Yes | Yes | TRIPSIGNORProtMapperHPRDRLIMS-P_ProtMapperWang | TRIP:24385424ProtMapper:26563869SIGNOR:24858416HPRD:14976260 |
| TRPM7 | Q96QT4 | PLCG2 | P16885 | Yes | Yes | No | Sparser_ProtMapperPhosphoSite_norefSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:22759789ProtMapper:22759789PhosphoSite:22759789 |
| TRPM7 | Q96QT4 | EF2K | O00418 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperdbPTMREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:22216903ProtMapper:21112387PhosphoSite:23182879PhosphoSite:21112387dbPTM:21112387SIGNOR:21112387PhosphoSite:32054489 |
| TRPM7 | Q96QT4 | ANXA1 | P04083 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAHPRDPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperHPRD-phos | HPRD:15485879PhosphoSite:21280599ProtMapper:26218331SIGNOR:24103589ProtMapper:34158860ProtMapper:24103589ProtMapper:21280599ProtMapper:15485879ProtMapper:20068231ProtMapper:24465463HPRD-phos:15485879KEA:15485879HPRD-phos:20068231PhosphoSite:15485879ProtMapper:20180991ProtMapper:33523920ProtMapper:20932259 |
| TRPM7 | Q96QT4 | TMOD1 | P28289 | Yes | No | No | PhosphoSite_MIMPMIMPPhosphoSite_norefiPTMnetProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:28226242PhosphoSite:19137675 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Channel complex TRPM6-TRPM7 | TRPM6TRPM7 | Q96QT4Q9BX84 | 1:1 | CompleatCORUM | Compleat:HC2771CORUM:558 | 14976260 |
| SNAP29TRPM7 | O95721Q96QT4 | 0:0 | hu.MAP | |||
| ARL15IREB2TRPM7 | P48200Q96QT4Q9NXU5 | 0:0:0 | hu.MAP2 | |||
| MYH14TRPM6TRPM7 | Q7Z406Q96QT4Q9BX84 | 1:1:1 | CompleatCFinder | Compleat:HC5356 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 28240915 |
Sequence, Structure & Domains
Sequences
Length
1,865
Mass
212,697
Sequence
MSQKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDVKLGDHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFNFGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLVRDVKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNTSSSTPQLRKSHESFGNRADKKEKMRHNHFIKTAQPYRPKIDTVMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQMTMDDSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSVQEWIVIAYIFTYAIEKVREIFMSEAGKVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPHEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVCANDSVIPQICGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFCCICKRRKKDKTSDGPKLFLTEEDQKKLHDFEEQCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQNLIDDGPVRPSVWKKHGVVNTLSSSLPQGDLESNNPFHCNILMKDDKDPQCNIFGQDLPAVPQRKEFNFPEAGSSSGALFPSAVSPPELRQRLHGVELLKIFNKNQKLGSSSTSIPHLSSPPTKFFVSTPSQPSCKSHLETGTKDQETVCSKATEGDNTEFGAFVGHRDSMDLQRFKETSNKIKILSNNNTSENTLKRVSSLAGFTDCHRTSIPVHSKQAEKISRRPSTEDTHEVDSKAALIPDWLQDRPSNREMPSEEGTLNGLTSPFKPAMDTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVQCTWSEHDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAEEKRSCDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKIIFPQDEPSDLNLQPGNSTKESESTNSVRLML
3D Structural Models
Domain & Motif Annotations
Compositional Bias
544..555; Low complexity; 560..573; Basic and acidic residues; 1386..1398; Low complexity; 1494..1511; Basic and acidic residues; 1844..1865; Polar residues
Coiled Coil
1198..1250
Domain (FT)
1594..1824; Alpha-type protein kinase
Region
544..575; Disordered; 1386..1407; Disordered; 1492..1511; Disordered; 1524..1543; Disordered; 1836..1865; Disordered
Protein Families
- Protein kinase superfamily, Alpha-type protein kinase family, ALPK subfamily
- Transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM7 sub-subfamily
Sequence Similarities
In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.; SIMILARITY: In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily.