Protein detail
PCD15
Protocadherin-15
Entry name PCD15 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protocadherin-15
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Eye disease
- Human disease related genes:Nervous system diseases:Ear disease
Transmembrane
1377..1397; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesSecretome LocationIntracellular and membraneSecretome FunctionReceptor
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Eye disease
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
30 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | Yes | Yes | No |
| ecm | ecm | OmniPath | Yes | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | LOCATE | No | No | Yes | Yes | No |
| intracellular | intracellular | ComPPI | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | Yes | Yes | No |
| cadherin_related | cell_adhesion | HGNC | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | Zhong2015 | Yes | Yes | Yes | Yes | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | Yes | Yes | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PCD15 | Q96QU1 | TMC2 | Q8TDI7 | Yes | Yes | No | SIGNOR | SIGNOR:25114259 |
| PCD15 | Q96QU1 | TMC1 | Q8TDI8 | Yes | Yes | No | SIGNOR | SIGNOR:25114259 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
1,955
Mass
216,069
Sequence
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=A, CD1-1; IsoId=Q96QU1-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q96QU1-2; Sequence=VSP_028257, VSP_028258; Name=3; Synonyms=C; IsoId=Q96QU1-3; Sequence=VSP_028259, VSP_028260; Name=4; Synonyms=CD2-1; IsoId=Q96QU1-4; Sequence=VSP_046616, VSP_046617, VSP_046622; Name=5; Synonyms=CD3-1; IsoId=Q96QU1-6; Sequence=VSP_046618, VSP_046621; Name=7; IsoId=Q96QU1-7; Sequence=VSP_062482, VSP_062483
Alternative Sequence
1..1118; Missing (in isoform 2); 435; D -> DVPPSGVP (in isoform 4); 957..961; GLPAS -> VSRRH (in isoform 3); 962..1955; Missing (in isoform 3); 1119..1125; LRVPSKS -> MTFSHSG (in isoform 2); 1456..1776; ILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSL -> MYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEEEPKKIKKPKVEIREPSEEEEVVVTIEKPPAAEPTYTTWKRARIFPMIFKKVRGLADKRGIVDLEGEEWQRRLEEEDKDYLKLTLDQEEATESTVESEEESSSDYTEYSEEESEFSESETTEEESESETPSEEEESSTPESEESESTESEGEKARKNIVLARRRPMVEEVKEVKGRKEEPQEEQKEPKMEEEEHSEEEESGPAPVEESTDPEAQDIPEEGSAESASVEGGVESEEESESGSSSSSSESQSGGPWGYQVPAYDRSKNANQKKSPGANSEGYNTAL (in isoform 4); 1456..1675; ILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLP -> MYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEWARKRMIKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRACLTDNLKVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPVGTDNTAVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMTKL (in isoform 5); 1457..1740; LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNI -> WSFCWQLVICMRTCAIWRTLTRRGYGSEQQQLLRPSLLKPEELSMESGIDPGQEYGQDYYSYEHGYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEWARKRMIKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRACLTDNLKVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPVGTDNTAVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMTKL (in isoform 7); 1676..1955; Missing (in isoform 5); 1741..1955; Missing (in isoform 7); 1777..1955; Missing (in isoform 4)
3D Structural Models
Turn
89..92; 107..109; 123..125; 169..174; 209..211; 222..224; 342..344; 355..357; 431..433; 449..451; 471..473; 560..562; 591..593; 846..848; 862..864; 869..871; 983..985; 1084..1086; 1097..1099; 1116..1118
Helix
81..83; 182..185; 200..203; 292..295; 316..318; 334..337; 539..541; 859..861; 882..884; 959..961; 973..978; 1029..1031; 1112..1115
Beta Strand
36..38; 40..47; 55..58; 62..64; 66..70; 73..79; 85..88; 93..96; 113..122; 128..138; 146..150; 152..157; 165..167; 175..177; 187..192; 214..216; 227..236; 241..243; 247..257; 264..266; 281..287; 300..302; 305..307; 309..311; 313..315; 322..331; 338..340; 347..349; 360..372; 377..386; 394..405; 415..417; 426..429; 442..447; 452..454; 456..461; 463..467; 476..484; 493..500; 512..519; 527..530; 544..550; 555..558; 564..567; 578..587; 596..606; 818..829; 837..840; 853..856; 865..867; 873..878; 891..899; 908..917; 924..927; 929..935; 944..947; 950..952; 964..968; 979..981; 987..992; 1001..1009; 1012..1014; 1017..1026; 1034..1036; 1038..1040; 1054..1057; 1067..1074; 1080..1082; 1088..1091; 1102..1111; 1127..1135
3D Structure
X-ray crystallography (8)
Domain & Motif Annotations
Compositional Bias
1426..1444; Pro residues; 1928..1941; Polar residues
Domain (CC)
Cadherin repeats 1 and 2 mediate calcium-dependent heterophilic interaction with CDH23..; DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain (FT)
40..147; Cadherin 1; 148..265; Cadherin 2; 278..395; Cadherin 3; 396..509; Cadherin 4; 510..616; Cadherin 5; 617..717; Cadherin 6; 719..819; Cadherin 7; 820..926; Cadherin 8; 927..1035; Cadherin 9; 1037..1144; Cadherin 10; 1145..1259; Cadherin 11
Region
1426..1446; Disordered; 1601..1623; Disordered; 1745..1766; Disordered; 1928..1955; Disordered